1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. COX
    Lipoxygenase
  3. Phenidone

Phenidone 

Cat. No.: HY-W010144 Purity: >98.0%
Handling Instructions

Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Phenidone is used as a photographic developer.

For research use only. We do not sell to patients.

Phenidone Chemical Structure

Phenidone Chemical Structure

CAS No. : 92-43-3

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10 mM * 1 mL in DMSO USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].

IC50 & Target[1]

COX

 

LOX

 

In Vitro

Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

162.19

Formula

C₉H₁₀N₂O

CAS No.

92-43-3

SMILES

O=C1NN(C2=CC=CC=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (616.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1656 mL 30.8280 mL 61.6561 mL
5 mM 1.2331 mL 6.1656 mL 12.3312 mL
10 mM 0.6166 mL 3.0828 mL 6.1656 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PhenidoneCOXLipoxygenaseCyclooxygenaseLOXautoimmunehypertensivebloodpressureoralphotographicdeveloperInhibitorinhibitorinhibit

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Product Name:
Phenidone
Cat. No.:
HY-W010144
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