92-43-3
92-43-3
Chemical Structure
Phenidone
- CAS No.: 92-43-3
- Formula:C9H10N2O
- Molecular Weight:162.19
IUPAC Name: 1-phenylpyrazolidin-3-one
InChIKey: CMCWWLVWPDLCRM-UHFFFAOYSA-N
SMILES: O=C1NN(C2=CC=CC=C2)CC1
Biological Activity: Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phenidone | 98.96% | Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Phenidone is used as a photographic developer. | ||||||||||||||||||||
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Phenidone (Standard) | ≥98% | Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Phenidone is used as a photographic developer. | ||||||||||||||||||||
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Nitrosobenzene | 99.32% | Nitrosobenzene is a radical scavenger that can be used to study oxidative DNA damage and the respiratory burst reaction of neutrophils induced by nitro compounds. | ||||||||||||||||||||
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CRBN ligand-1 | CRBN ligand-1 is a ligand for E3 ligase. | |||||||||||||||||||||
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Phenylpiperazine (Standard) | ≥98% | Phenylpiperazine (Standard) is the analytical standard of Phenylpiperazine. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Edaravone | 99.94% | Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. | ||||||||||||||||||||
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3,4-Dihydroquinolin-2(1H)-one | 3,4-Dihydroquinolin-2(1H)-one is a building block, that can be used for synthesis of antipsychotic agent, such as Aripiprazole (HY-14546) or CYP11B2 inhibitors. | |||||||||||||||||||||
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Phenylpiperazine hydrochloride | Phenylpiperazine hydrochloride (Piperazine, 1-phenyl-, dihydrochloride) is the base compound from which a broad series of bioactive products are derived. | |||||||||||||||||||||
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N'-Phenylacetohydrazide | 99.99% | N'-Phenylacetohydrazide consists of a phenyl group attached to the acetylhydrazide functional group via a hydrazine bond. This compound is commonly used as a reagent in organic chemistry for the determination of carbonyl compounds such as aldehydes and ketones. | ||||||||||||||||||||
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3-Methylindolin-2-one | 98.89% | 3-Methylindolin-2-one is an endogenous metabolite. | ||||||||||||||||||||
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1-Phenyl-2-pyrrolidinone | 99.86% | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes. | ||||||||||||||||||||
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Indoline | 99.89% | Indoline is a derivative of Indole (HY-W001132). Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range. | ||||||||||||||||||||
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References
- [1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [Content Brief]
- [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [Content Brief]
- [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587. [Content Brief]
