N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase

  • Bioorg Med Chem Lett. 2001 Mar 26;11(6):845-8. doi: 10.1016/s0960-894x(01)00077-4.
C Audouin  1 ,  N Mestdagh ,  M A Lassoie ,  R Houssin ,  J P Hénichart
Affiliations
  • 1. Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, France.
PMID: 11277534 DOI: 10.1016/s0960-894x(01)00077-4
Abstract

N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.