Ac-Leu-Val-Lys-Aldehyde
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II.
For research use only. We do not sell to patients.
- CAS No.: 147600-40-6
- Formula: C19H36N4O4
- Molecular Weight:384.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
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Cathepsin B 4 nM (IC50) |
Chemical Information
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CAS No. 147600-40-6
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Molecular Weight 384.51
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Formula C19H36N4O4
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Sequence
Ac-Leu-Val-{Lys-Aldehyde}
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Sequence Shortening
Ac-LV-{Lys-Aldehyde}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. [Content Brief]
[2]. Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac-Leu-Val-Lys-Aldehyde Related Classifications
HY-P4532 Related Classifications
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