1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. FAAH
  3. SSR411298

SSR411298 

Cat. No.: HY-123863
Handling Instructions

SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research.

For research use only. We do not sell to patients.

SSR411298 Chemical Structure

SSR411298 Chemical Structure

CAS No. : 666860-59-9

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Description

SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research[1].

In Vitro

SSR411298 (0.1, 1, 10, 100, 1000, 10000 nM) inhibits mouse brain FAAH in a concentration-dependent manner[1].
SSR411298 produces maximal inhibition of FAAH between 0.3 and 30 mg/kg in the ex-vivo experiment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SSR411298 (0.3, 1, 3 mg/kg; p.o.; twice a day during 2 days; 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing) produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress model, restoring notably the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g[1].
SSR411298 (0.3, 1, 3, 10 mg/kg; po; single dose; two hours prior to sacrifice) produces a significant global increase of tissular AEA, PEA and OEA levels in the hippocampus, but not of 2-AG levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.44

Formula

C₂₁H₂₆N₂O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SSR411298
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