2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH
  4. SSR411298

SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research.

For research use only. We do not sell to patients.

SSR411298 Chemical Structure

SSR411298 Chemical Structure

CAS No. : 666860-59-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 561 In-stock
Solution
10 mM * 1 mL in DMSO USD 561 In-stock
Solid
5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1680 In-stock
50 mg USD 2650 In-stock
100 mg USD 4200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

SSR411298 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research[1].

In Vitro

SSR411298 (0.1, 1, 10, 100, 1000, 10000 nM) inhibits mouse brain FAAH in a concentration-dependent manner[1].
SSR411298 produces maximal inhibition of FAAH between 0.3 and 30 mg/kg in the ex-vivo experiment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SSR411298 Related Antibodies
In Vivo

SSR411298 (0.3, 1, 3 mg/kg; p.o.; twice a day during 2 days; 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing) produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress model, restoring notably the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g[1].
SSR411298 (0.3, 1, 3, 10 mg/kg; po; single dose; two hours prior to sacrifice) produces a significant global increase of tissular AEA, PEA and OEA levels in the hippocampus, but not of 2-AG levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

402.44

Formula

C21H26N2O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COC1=CC2=C(C=C1)C([C@@H]3CO[C@H](OC3)CCCNC(OCC(N)=O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4848 mL 12.4242 mL 24.8484 mL
5 mM 0.4970 mL 2.4848 mL 4.9697 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4848 mL 12.4242 mL 24.8484 mL 62.1211 mL
5 mM 0.4970 mL 2.4848 mL 4.9697 mL 12.4242 mL
10 mM 0.2485 mL 1.2424 mL 2.4848 mL 6.2121 mL
15 mM 0.1657 mL 0.8283 mL 1.6566 mL 4.1414 mL
20 mM 0.1242 mL 0.6212 mL 1.2424 mL 3.1061 mL
25 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
30 mM 0.0828 mL 0.4141 mL 0.8283 mL 2.0707 mL
40 mM 0.0621 mL 0.3106 mL 0.6212 mL 1.5530 mL
50 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
60 mM 0.0414 mL 0.2071 mL 0.4141 mL 1.0354 mL
80 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7765 mL
100 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
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SSR411298 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SSR411298666860-59-9SSR 411298SSR-411298FAAHFatty acid amide hydrolaseorallyfattyacidamidepost-traumaticstressInhibitorinhibitorinhibit

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