2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly  (Synonyms: FAPGG)

Cat. No.: HY-W010991 Pureza: 99.81%
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Instrucciones de manejo Technical Support

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system.

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N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Estructura química

No. CAS : 64967-39-1

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Related Antibodies

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1 Publications Citing Use of MCE N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

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Descripciòn

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system[1].

In Vitro

In the spectrophotometric ACE inhibition assay, N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG; 1×10-3-1×10-4 M; 5 min) is hydrolyzed by ACE with a Km of 2.546×10-4 M[1].
In the TLC-based ACE activity assay, N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG; 5×10-4 M; 10 min) reduces FAP production in the dioscorin-treated group, confirming its ACE inhibitory effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Related Antibodies
Peso molecular

399.40

Fòrmula

C20H21N3O6
No. CAS
Appearance

Solid

Color

White to off-white

Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (250.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5038 mL 12.5188 mL 25.0376 mL
5 mM 0.5008 mL 2.5038 mL 5.0075 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Pureza y Documentación

Purity: 99.81%

SDS (394 KB)

COA (247 KB) HNMR (307 KB) RP-HPLC (259 KB) LCMS (95 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5038 mL 12.5188 mL 25.0376 mL 62.5939 mL
5 mM 0.5008 mL 2.5038 mL 5.0075 mL 12.5188 mL
10 mM 0.2504 mL 1.2519 mL 2.5038 mL 6.2594 mL
15 mM 0.1669 mL 0.8346 mL 1.6692 mL 4.1729 mL
20 mM 0.1252 mL 0.6259 mL 1.2519 mL 3.1297 mL
25 mM 0.1002 mL 0.5008 mL 1.0015 mL 2.5038 mL
30 mM 0.0835 mL 0.4173 mL 0.8346 mL 2.0865 mL
40 mM 0.0626 mL 0.3130 mL 0.6259 mL 1.5648 mL
50 mM 0.0501 mL 0.2504 mL 0.5008 mL 1.2519 mL
60 mM 0.0417 mL 0.2086 mL 0.4173 mL 1.0432 mL
80 mM 0.0313 mL 0.1565 mL 0.3130 mL 0.7824 mL
100 mM 0.0250 mL 0.1252 mL 0.2504 mL 0.6259 mL
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N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly64967-39-1FAPGGAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Nombre del producto:
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
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HY-W010991
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