64967-39-1
![N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-w010991.gif "N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Chemical Structure")
Chemical Structure
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
Synonym(s): FAPGG
- CAS. Nr.: 64967-39-1
- Formula:C20H21N3O6
- Molecular Weight:399.40
IUPAC Name: (E)-(E)-(3-(furan-2-yl)acryloyl)-L-phenylalanylglycylglycine
InChIKey: ZDLZKMDMBBMJLI-FDMDGMSGSA-N
SMILES: O=C(O)CNC(CNC([C@@H](NC(/C=C/C1=CC=CO1)=O)CC2=CC=CC=C2)=O)=O
Biological Activity: N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system[1].
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N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly | 99.81% | N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system. | ||||||||||||||||||||
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Keywords
