2. Antibody-drug Conjugate/ADC Related Others
  3. ADC Linker Drug Intermediate
  4. Gly-Gly-Phe-Gly

Gly-Gly-Phe-Gly is a peptide spacer and can be applied to Doxorubicin (HY-15142A) (DXR) conjugates. Gly-Gly-Phe-Gly can be used as an ADC linker to synthesize ADCs, such as Puxitatug samrotecan (AZD 8205) (HY-171689).

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Gly-Gly-Phe-Gly

Gly-Gly-Phe-Gly Estructura química

No. CAS : 200427-88-9

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Based on 1 publication(s) in Google Scholar

Gly-Gly-Phe-Gly Related Antibodies

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Descripciòn

Gly-Gly-Phe-Gly is a peptide spacer and can be applied to Doxorubicin (HY-15142A) (DXR) conjugates. Gly-Gly-Phe-Gly can be used as an ADC linker to synthesize ADCs, such as Puxitatug samrotecan (AZD 8205) (HY-171689)[1][2][3].

In Vitro

Gly-Gly-Phe-Gly can be efficiently recognized and cleaved by proteases in tumor tissues, and the release rate of its associated DXR prodrug is relatively fast. It is an ideal fast-release type peptide linker[1].
Gly-Gly-Phe-Gly can be specifically cleaved in lysosomes and can be used as an ADC linker to construct ADCs. This peptide linker remains stable during systemic circulation, which helps to reduce systemic toxicity[2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gly-Gly-Phe-Gly Related Antibodies
Peso molecular

336.34

Fòrmula

C15H20N4O5
No. CAS
Appearance

Solid

Color

White to off-white

Sequence Shortening

GGFG
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (297.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9732 mL 14.8659 mL 29.7318 mL
5 mM 0.5946 mL 2.9732 mL 5.9464 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9732 mL 14.8659 mL 29.7318 mL 74.3295 mL
5 mM 0.5946 mL 2.9732 mL 5.9464 mL 14.8659 mL
10 mM 0.2973 mL 1.4866 mL 2.9732 mL 7.4330 mL
15 mM 0.1982 mL 0.9911 mL 1.9821 mL 4.9553 mL
20 mM 0.1487 mL 0.7433 mL 1.4866 mL 3.7165 mL
25 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9732 mL
30 mM 0.0991 mL 0.4955 mL 0.9911 mL 2.4777 mL
40 mM 0.0743 mL 0.3716 mL 0.7433 mL 1.8582 mL
50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4866 mL
60 mM 0.0496 mL 0.2478 mL 0.4955 mL 1.2388 mL
80 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9291 mL
100 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7433 mL
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Gly-Gly-Phe-Gly Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gly-Gly-Phe-Gly200427-88-9ADC LinkerDrug IntermediateAntibody-drug conjugates linkerDrug IintermediateInhibitorinhibitorinhibit

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Nombre del producto:
Gly-Gly-Phe-Gly
Cat. No.:
HY-P3669
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