200427-88-9
Chemical Structure
Gly-Gly-Phe-Gly
- CAS No.: 200427-88-9
- Formula:C15H20N4O5
- Molecular Weight:336.34
IUPAC Name: 2,2'-((2Z,2'Z)-((6,12,13-tris(2-butyloctyl)-3,9-diundecyl-12,13-dihydro-6H-thieno[2'',3'':4',5']thieno[2',3':4,5]pyrrolo[3,2-g]thieno[2',3':4,5]thieno[3,2-b][1,2,3]triazolo[4,5-e]indole-2,10-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile compound with bromomethane (1:2)
InChIKey: HXUVTXPOZRFMOY-NSHDSACASA-N
SMILES: NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O
Biological Activity: Gly-Gly-Phe-Gly is a peptide spacer and can be applied to Doxorubicin (HY-15142A) (DXR) conjugates. Gly-Gly-Phe-Gly can be used as an ADC linker to synthesize ADCs, such as Puxitatug samrotecan (AZD 8205) (HY-171689)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gly-Gly-Phe-Gly | 99.97% | Gly-Gly-Phe-Gly is a peptide spacer and can be applied to Doxorubicin (HY-15142A) (DXR) conjugates. Gly-Gly-Phe-Gly can be used as an ADC linker to synthesize ADCs, such as Puxitatug samrotecan (AZD 8205) (HY-171689). | ||||||||||||||||||||
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References
- [1]. Shiose Y, et al. Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates. Bioconjug Chem. 2009 Jan;20(1):60-70. [Content Brief]
- [2]. Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-1545. [Content Brief]
- [3]. Kinneer K, et al. Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305. Clin Cancer Res. 2023 Mar 14;29(6):1086-1101. [Content Brief]
