2. Signaling Pathways
  3. Antibody-Drug Conjugate/ADC Related
  4. ADC Linker
  5. Glycosidase Cleavable Linker Isoform

Glycosidase Cleavable Linker

Glycosidase cleavable linkers use enzyme-triggered hydrolysis to connect targeted ligands or prodrugs with cytotoxic payloads, supporting selective release at tumor cells or defined biological sites[1][2]. Mechanistically, β-glucuronide linkers can be cleaved by lysosomal β-glucuronidase, and this design enabled CS5001 to release a DNA-crosslinking PBD dimer in ROR1-expressing malignancy models[3]. In antibody-enzyme prodrug therapy, a monoclonal antibody-β-glucuronidase conjugate activated epirubicin-glucuronide at antigen-positive tumor cells, restoring cytotoxicity after prodrug hydrolysis[4]. Compared with non-cleavable or nonspecifically labile linkers, ideal ADC linkers should remain stable in circulation and release payload specifically in tumors, because nonspecific release contributes to off-target toxicity[2]. Glycosylated paclitaxel prodrugs also showed improved solubility, serum release behavior, and β-glucuronidase-mediated parent-drug release, supporting glycosylation as a practical prodrug modification strategy[5]. Therefore, glycosidase cleavable linkers provide research value for ADCs, prodrugs, and targeted drug conjugates when linker stability, enzyme access, tumor selectivity, and payload release must be experimentally balanced[1][2][5].

Glycosidase Cleavable Linker Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-136329
    β-D-glucuronide-pNP-carbonate
    		99.60%
    β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-44222
    MAC glucuronide linker-2
    		99.22%
    MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-44221
    MAC glucuronide linker-1
    MAC glucuronide linker-1 is a claevable ADC linker for antibody-agent-conjugations (ADCs).
  • HY-131087
    Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc
    		98.84%
    Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-131086
    Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2
    		98.58%
    Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-136318
    β-D-tetraacetylgalactopyranoside-PEG1-N3
    		98.0%
    β-D-tetraacetylgalactopyranoside-PEG1-N3 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). β-D-tetraacetylgalactopyranoside-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.