1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. β-D-glucuronide-pNP-carbonate

β-D-glucuronide-pNP-carbonate 

Cat. No.: HY-136329 Purity: 99.44%
COA Handling Instructions

β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

β-D-glucuronide-pNP-carbonate Chemical Structure

β-D-glucuronide-pNP-carbonate Chemical Structure

CAS No. : 894095-98-8

Size Price Stock Quantity
50 mg USD 500 In-stock
100 mg USD 914 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Glycosidase Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

913.83

Formula

C45H43N3O18

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC(NC(C=C1COC(OC(C=C2)=CC=C2[N+]([O-])=O)=O)=C(C=C1)O[C@H](O[C@@H]3C(OC)=O)[C@@H]([C@H]([C@@H]3OC(C)=O)OC(C)=O)OC(C)=O)=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (273.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0943 mL 5.4715 mL 10.9430 mL
5 mM 0.2189 mL 1.0943 mL 2.1886 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0943 mL 5.4715 mL 10.9430 mL 27.3574 mL
5 mM 0.2189 mL 1.0943 mL 2.1886 mL 5.4715 mL
10 mM 0.1094 mL 0.5471 mL 1.0943 mL 2.7357 mL
15 mM 0.0730 mL 0.3648 mL 0.7295 mL 1.8238 mL
20 mM 0.0547 mL 0.2736 mL 0.5471 mL 1.3679 mL
25 mM 0.0438 mL 0.2189 mL 0.4377 mL 1.0943 mL
30 mM 0.0365 mL 0.1824 mL 0.3648 mL 0.9119 mL
40 mM 0.0274 mL 0.1368 mL 0.2736 mL 0.6839 mL
50 mM 0.0219 mL 0.1094 mL 0.2189 mL 0.5471 mL
60 mM 0.0182 mL 0.0912 mL 0.1824 mL 0.4560 mL
80 mM 0.0137 mL 0.0684 mL 0.1368 mL 0.3420 mL
100 mM 0.0109 mL 0.0547 mL 0.1094 mL 0.2736 mL
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β-D-glucuronide-pNP-carbonate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
β-D-glucuronide-pNP-carbonate
Cat. No.:
HY-136329
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