β-D-glucuronide-pNP-carbonate
Based on 1 Customer Validation
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 894095-98-8
- Formula: C45H43N3O18
- Molecular Weight:913.83
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Glycosidase Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 894095-98-8
-
Appearance Solid
-
Molecular Weight 913.83
-
Formula C45H43N3O18
-
Color White to off-white
-
SMILES
O=C(NCCC(NC(C=C1COC(OC(C=C2)=CC=C2[N+]([O-])=O)=O)=C(C=C1)O[C@H](O[C@@H]3C(OC)=O)[C@@H]([C@H]([C@@H]3OC(C)=O)OC(C)=O)OC(C)=O)=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 133.33 mg/mL (145.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0943 mL | 5.4715 mL | 10.9430 mL | 27.3574 mL |
| 5 mM | 0.2189 mL | 1.0943 mL | 2.1886 mL | 5.4715 mL | |
| 10 mM | 0.1094 mL | 0.5471 mL | 1.0943 mL | 2.7357 mL | |
| 15 mM | 0.0730 mL | 0.3648 mL | 0.7295 mL | 1.8238 mL | |
| 20 mM | 0.0547 mL | 0.2736 mL | 0.5471 mL | 1.3679 mL | |
| 25 mM | 0.0438 mL | 0.2189 mL | 0.4377 mL | 1.0943 mL | |
| 30 mM | 0.0365 mL | 0.1824 mL | 0.3648 mL | 0.9119 mL | |
| 40 mM | 0.0274 mL | 0.1368 mL | 0.2736 mL | 0.6839 mL | |
| 50 mM | 0.0219 mL | 0.1094 mL | 0.2189 mL | 0.5471 mL | |
| 60 mM | 0.0182 mL | 0.0912 mL | 0.1824 mL | 0.4560 mL | |
| 80 mM | 0.0137 mL | 0.0684 mL | 0.1368 mL | 0.3420 mL | |
| 100 mM | 0.0109 mL | 0.0547 mL | 0.1094 mL | 0.2736 mL |
β-D-glucuronide-pNP-carbonate Related Classifications
HY-136329 Related Classifications
Powered by Bioz