1. Protein Tyrosine Kinase/RTK
  2. Src
  3. Osteogenic Growth Peptide (10-14)

Osteogenic Growth Peptide (10-14) (Synonyms: OGP(10-14); Historphin)

Cat. No.: HY-107024
Handling Instructions

Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Osteogenic Growth Peptide (10-14) Chemical Structure

Osteogenic Growth Peptide (10-14) Chemical Structure

CAS No. : 105250-85-9

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Description

Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].

In Vitro

Osteogenic Growth Peptide (10-14) (OGP(10-14)) induces proliferation and differentiation in fibroblast and osteoblast cell lines[3].
Osteogenic Growth Peptide (10-14) induces TPO-primed M07-e cells differentiation through RhoA/TGFβ1/SFKs signalling pathway. In particular Historphin acts as a Src inhibitor, showing the same effects of PP2[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.52

Formula

C₂₄H₂₉N₅O₇

CAS No.

105250-85-9

Sequence Shortening

YGFGG

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Osteogenic Growth Peptide (10-14)OGP(10-14) HistorphinSrcpentapeptideosteogenicgrowthpeptidemitogenosteogenesishematopoiesisboneInhibitorinhibitorinhibit

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Product Name:
Osteogenic Growth Peptide (10-14)
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HY-107024
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