1. Metabolic Enzyme/Protease
    Epigenetics
  2. Endogenous Metabolite
    Histone Demethylase
  3. Eicosapentaenoic Acid sodium

Eicosapentaenoic Acid sodium (Synonyms: EPA sodium; Timnodonic acid sodium)

Cat. No.: HY-W011269
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Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation.

For research use only. We do not sell to patients.

Eicosapentaenoic Acid sodium Chemical Structure

Eicosapentaenoic Acid sodium Chemical Structure

CAS No. : 73167-03-0

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Description

Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

IC50 & Target[1][2][3]

Human Endogenous Metabolite

 

In Vitro

C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1].
Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.43

Formula

C20H29NaO2

CAS No.
SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[Na])=O

Structure Classification
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Eicosapentaenoic Acid sodium
Cat. No.:
HY-W011269
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