2. Metabolic Enzyme/Protease Epigenetics
  3. Endogenous Metabolite Histone Demethylase
  4. Eicosapentaenoic Acid sodium

Eicosapentaenoic Acid sodium  (Synonyms: EPA sodium; Timnodonic acid sodium)

Cat. No.: HY-W011269 Purity: 95.78%
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Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation.

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CAS No. : 73167-03-0

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Based on 30 publication(s) in Google Scholar

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Eicosapentaenoic Acid sodium Related Antibodies

Top Publications Citing Use of Products

30 Publications Citing Use of MCE Eicosapentaenoic Acid sodium

In Vivo Efficacy Study
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Cell Proliferation/Viability Assay
ELISA

    Eicosapentaenoic Acid sodium purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805.  [Abstract]

    Immunoblot analysis of HCC1806 cells following 16 hour serum starvation and subsequent stimulation with 10% FBS or 30 μM ω-6 LA or Arachidonic acid (AA), or ω-3 ALA, Eicosapentaenoic acid (EPA) or Docosahexaenoic acid (DHA) for 30 minutes.

    Eicosapentaenoic Acid sodium purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805.  [Abstract]

    HCC1806 cells were serum starved for 16 hours and subsequently restimulated for 30 minutes with 1μM, 5μM, 10μM, 30μM, 100μM, 200μM, 1000μM of ω-6 LA, ω-6 ARA, ω-3 ALA, ω-3 EPA and ω-3 DHA for 30 minutes. Intracellular concentrations of each PUFA were quantified by ELISA from lysates obtained from 5 x 106 cells.

    Eicosapentaenoic Acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 and A2780 cells were cultured in fatty acid-free media supplemented with 50 μM AA (Arachidonic acid), 50 μM OA (Oleic acid), 50 μM EPA (Eicosapentaenoic acid), 50 μM PA (Palmitic acid), and 50 μM MA (Myristic acid) with the treatment of 10 μM Niraparib for 72 h, and the cell viability was determined.

    Eicosapentaenoic Acid sodium purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 May 17:107214.  [Abstract]

    Eicosapentaenoic acid (EPA; 150 mg/kg; oral). Behavioral tests for the forced swim test.

    Eicosapentaenoic Acid sodium purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118.  [Abstract]

    Western blot analysis showing the protein levels of HIF-1A, COL1A1, and α-SMA in HSFs treated with 5-20 μM DHA/EPA and under 21% (normoxic) or 5% (hypoxic) oxygen levels.

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    Description

    Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

    IC50 & Target[1][2][3]

    Human Endogenous Metabolite

     

    In Vitro

    C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1].
    Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Eicosapentaenoic Acid sodium Related Antibodies
    Molecular Weight

    324.43

    Formula

    C20H29NaO2
    CAS No.
    Appearance

    Solid

    Color

    Orange to red

    SMILES

    CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[Na])=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Purity & Documentation
    References
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    Eicosapentaenoic Acid sodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Eicosapentaenoic Acid73167-03-0EPATimnodonic acidEndogenous MetaboliteHistone Demethylaselong-chain polyunsaturated fatty acidω-3 LC-PUFADNA demethylatingCCAATC/EBPδRASERKC/EBPβH-Ras intron 1 CpG islandInhibitorinhibitorinhibit

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