Vigabatrin
Based on 6 publication(s) in Google Scholar
Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 68506-86-5
- Formula: C6H11NO2
- Molecular Weight:129.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Vigabatrin
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Bio/Physico-chemical Assay
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IF
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Bio/Physico-chemical Assay
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ELISA
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ELISA
Biological Activity
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 68506-86-5
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Appearance Solid
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Molecular Weight 129.16
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Formula C6H11NO2
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Color White to off-white
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SMILES
C=CC(N)CCC(O)=O
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Synonyms
γ-Vinyl-GABA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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Redox Biol
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]2021 Oct:46:102082. PMID: 34343908 -
Cell Rep
2022 Dec 6;41(10):111770. PMID: 36476877
Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on FAD production in M0 macrophages.
Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on inflammasome activation in M1 macrophages.
Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on mitochondrial functions in M1 macrophages.
Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on IL-1β productionin in M1 macrophages.
Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) promoted IL-1β production in macrophages without GABA treatment.
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J Exp Bot
2020 Feb 19;71(4):1459-1474. PMID: 31740934 -
Plants
Effects of GABA and Vigabatrin on the Germination of Chinese Chestnut Recalcitrant Seeds and Its Implications for Seed Dormancy and Storage. [Abstract]2020 Apr 3;9(4):449. PMID: 32260136 -
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Animals
2020 Mar 27;10(4):567. PMID: 32230949
Solvent & Solubility
H2O : 50 mg/mL (387.12 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (774.23 mM); Suspended solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [Content Brief]
[2]. Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7. [Content Brief]
[3]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.7423 mL | 38.7117 mL | 77.4233 mL | 193.5584 mL |
| 5 mM | 1.5485 mL | 7.7423 mL | 15.4847 mL | 38.7117 mL | |
| 10 mM | 0.7742 mL | 3.8712 mL | 7.7423 mL | 19.3558 mL | |
| 15 mM | 0.5162 mL | 2.5808 mL | 5.1616 mL | 12.9039 mL | |
| 20 mM | 0.3871 mL | 1.9356 mL | 3.8712 mL | 9.6779 mL | |
| 25 mM | 0.3097 mL | 1.5485 mL | 3.0969 mL | 7.7423 mL | |
| 30 mM | 0.2581 mL | 1.2904 mL | 2.5808 mL | 6.4519 mL | |
| 40 mM | 0.1936 mL | 0.9678 mL | 1.9356 mL | 4.8390 mL | |
| 50 mM | 0.1548 mL | 0.7742 mL | 1.5485 mL | 3.8712 mL | |
| 60 mM | 0.1290 mL | 0.6452 mL | 1.2904 mL | 3.2260 mL | |
| 80 mM | 0.0968 mL | 0.4839 mL | 0.9678 mL | 2.4195 mL | |
| 100 mM | 0.0774 mL | 0.3871 mL | 0.7742 mL | 1.9356 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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