2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Vigabatrin

Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

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CAS No. : 68506-86-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Vigabatrin:

Vigabatrin Related Antibodies

Top Publications Citing Use of Products

    Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on FAD production in M0 macrophages.

    Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on inflammasome activation in M1 macrophages.

    Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on mitochondrial functions in M1 macrophages.

    Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on IL-1β productionin in M1 macrophages.

    Vigabatrin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) promoted IL-1β production in macrophages without GABA treatment.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

    In Vitro

    Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Vigabatrin Related Antibodies
    In Vivo

    A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    129.16

    Formula

    C6H11NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C=CC(N)CCC(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (387.12 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.7423 mL 38.7117 mL 77.4233 mL
    5 mM 1.5485 mL 7.7423 mL 15.4847 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (774.23 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.91%

    SDS (393 KB)

    COA (243 KB) HNMR (240 KB) RP-HPLC (273 KB) MS (227 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.7423 mL 38.7117 mL 77.4233 mL 193.5584 mL
    5 mM 1.5485 mL 7.7423 mL 15.4847 mL 38.7117 mL
    10 mM 0.7742 mL 3.8712 mL 7.7423 mL 19.3558 mL
    15 mM 0.5162 mL 2.5808 mL 5.1616 mL 12.9039 mL
    20 mM 0.3871 mL 1.9356 mL 3.8712 mL 9.6779 mL
    25 mM 0.3097 mL 1.5485 mL 3.0969 mL 7.7423 mL
    30 mM 0.2581 mL 1.2904 mL 2.5808 mL 6.4519 mL
    40 mM 0.1936 mL 0.9678 mL 1.9356 mL 4.8390 mL
    50 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
    60 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2260 mL
    80 mM 0.0968 mL 0.4839 mL 0.9678 mL 2.4195 mL
    100 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9356 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Vigabatrin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vigabatrin68506-86-5γ-Vinyl-GABAGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAantiepilepticγ-aminobutyricacidbraintransaminaseTauTInhibitorinhibitorinhibit

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