Referencia número: HY-B0033

Vigabatrin hydrochloride

(Synonyms: γ-Vinyl-GABA hydrochloride)

6 Cited Publications

Revisión del cliente

Based on 6 publication(s) in Google Scholar

Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.0%
No. CAS: 1391054-02-6
Fòrmula: C₆H₁₂ClNO₂
Peso molecular:165.62

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vigabatrin hydrochloride Chemical Structure

No. CAS: 1391054-02-6

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (6)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 1391054-02-6
Appearance Solid
Peso molecular 165.62
Fòrmula C₆H₁₂ClNO₂
Color White to off-white
SMILES

C=CC(N)CCC(O)=O.Cl
Synonyms

γ-Vinyl-GABA hydrochloride
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Bio/Physico-chemical AssayIFELISA

Sort by:

Journal Impact Factor

Redox Biol

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]

2021 Oct:46:102082. PMID: 34343908
Cell Rep

GABA regulates IL-1β production in macrophages. [Abstract]

2022 Dec 6;41(10):111770. PMID: 36476877

Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on FAD production in M0 macrophages.

Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on inflammasome activation in M1 macrophages.

Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on mitochondrial functions in M1 macrophages.

Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) rescued the effects of GABA on IL-1β productionin in M1 macrophages.

Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]

Vigabatrin (100 mg/kg) promoted IL-1β production in macrophages without GABA treatment.
J Exp Bot

GABA negatively regulates adventitious root development in poplar. [Abstract]

2020 Feb 19;71(4):1459-1474. PMID: 31740934
Plants

Effects of GABA and Vigabatrin on the Germination of Chinese Chestnut Recalcitrant Seeds and Its Implications for Seed Dormancy and Storage. [Abstract]

2020 Apr 3;9(4):449. PMID: 32260136
Horticulturae

2023, 9(2), 268.
Animals (Basel)

Effect of GABA-T on Reproductive Function in Female Rats. [Abstract]

2020 Mar 27;10(4):567. PMID: 32230949

Solvente y solubilidad

In Vitro:

H₂O : 33.33 mg/mL (201.24 mM; Need ultrasonic)

DMSO : 27.5 mg/mL (166.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.0379 mL

30.1896 mL

60.3792 mL

5 mM

1.2076 mL

6.0379 mL

12.0758 mL

10 mM

0.6038 mL

3.0190 mL

6.0379 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 10 mg/mL (60.38 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [Content Brief]

[2]. Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7. [Content Brief]

[3]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	6.0379 mL	30.1896 mL	60.3792 mL	150.9480 mL
	5 mM	1.2076 mL	6.0379 mL	12.0758 mL	30.1896 mL
	10 mM	0.6038 mL	3.0190 mL	6.0379 mL	15.0948 mL
	15 mM	0.4025 mL	2.0126 mL	4.0253 mL	10.0632 mL
	20 mM	0.3019 mL	1.5095 mL	3.0190 mL	7.5474 mL
	25 mM	0.2415 mL	1.2076 mL	2.4152 mL	6.0379 mL
	30 mM	0.2013 mL	1.0063 mL	2.0126 mL	5.0316 mL
	40 mM	0.1509 mL	0.7547 mL	1.5095 mL	3.7737 mL
	50 mM	0.1208 mL	0.6038 mL	1.2076 mL	3.0190 mL
	60 mM	0.1006 mL	0.5032 mL	1.0063 mL	2.5158 mL
	80 mM	0.0755 mL	0.3774 mL	0.7547 mL	1.8868 mL
	100 mM	0.0604 mL	0.3019 mL	0.6038 mL	1.5095 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

Vigabatrin hydrochloride

6 Cited Publications

100 mg Obtener un presupuesto

Subscribe to the

MedChemExpress

Newsletter

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Vigabatrin hydrochloride

Aminooxyacetic acid hemihydrochloride

Oxiracetam

Oxiracetam (Standard)