2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Vigabatrin hydrochloride

Vigabatrin hydrochloride  (Synonyms: γ-Vinyl-GABA hydrochloride)

Cat. No.: HY-B0033 Purity: 98.0%
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Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

For research use only. We do not sell to patients.

CAS No. : 1391054-02-6

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Vigabatrin hydrochloride:

Vigabatrin hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on FAD production in M0 macrophages.

    Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on inflammasome activation in M1 macrophages.

    Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on mitochondrial functions in M1 macrophages.

    Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) rescued the effects of GABA on IL-1β productionin in M1 macrophages.

    Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770.  [Abstract]

    Vigabatrin (100 mg/kg) promoted IL-1β production in macrophages without GABA treatment.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

    In Vitro

    A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Vigabatrin hydrochloride Related Antibodies
    In Vivo

    Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    165.62

    Formula

    C6H12ClNO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C=CC(N)CCC(O)=O.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 33.33 mg/mL (201.24 mM; Need ultrasonic)

    DMSO : 27.5 mg/mL (166.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0379 mL 30.1896 mL 60.3792 mL
    5 mM 1.2076 mL 6.0379 mL 12.0758 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (60.38 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (393 KB)

    COA (248 KB) HNMR (264 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 6.0379 mL 30.1896 mL 60.3792 mL 150.9480 mL
    5 mM 1.2076 mL 6.0379 mL 12.0758 mL 30.1896 mL
    10 mM 0.6038 mL 3.0190 mL 6.0379 mL 15.0948 mL
    15 mM 0.4025 mL 2.0126 mL 4.0253 mL 10.0632 mL
    20 mM 0.3019 mL 1.5095 mL 3.0190 mL 7.5474 mL
    25 mM 0.2415 mL 1.2076 mL 2.4152 mL 6.0379 mL
    30 mM 0.2013 mL 1.0063 mL 2.0126 mL 5.0316 mL
    40 mM 0.1509 mL 0.7547 mL 1.5095 mL 3.7737 mL
    50 mM 0.1208 mL 0.6038 mL 1.2076 mL 3.0190 mL
    60 mM 0.1006 mL 0.5032 mL 1.0063 mL 2.5158 mL
    80 mM 0.0755 mL 0.3774 mL 0.7547 mL 1.8868 mL
    100 mM 0.0604 mL 0.3019 mL 0.6038 mL 1.5095 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Vigabatrin hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vigabatrin1391054-02-6γ-Vinyl-GABAGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAantiepilepticγ-aminobutyricacidbraintransaminaseTauTInhibitorinhibitorinhibit

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