AGN 192870

Cat. No.: HY-105689: FAQs
Data Sheet Handling Instructions

AGN 192870 is a RAR neutral antagonist with K_ds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism.

For research use only. We do not sell to patients.

AGN 192870 Chemical Structure

CAS No. : 166977-57-7

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Description	AGN 192870 is a RAR neutral antagonist with K_ds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism^[1].
Molecular Weight	378.46
Formula	C₂₇H₂₂O₂
CAS No.	166977-57-7
SMILES	O=C(C1=CC=C(C=C1)C#CC2=CC(C(C3=CC=CC=C3)=CCC4(C)C)=C4C=C2)O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Klein ES, et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem. 1996;271(37):22692-22696. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

AGN 192870166977-57-7AGN192870AGN-192870RAR/RXRRetinoic acid receptorsRetinoid X receptorsretinoic acid receptorneutral antagonistInhibitorinhibitorinhibit

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AGN 192870

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

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