1. Others
  2. Others
  3. GET73

GET73 

Cat. No.: HY-108034
Handling Instructions

GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus.

For research use only. We do not sell to patients.

GET73 Chemical Structure

GET73 Chemical Structure

CAS No. : 202402-01-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].

In Vitro

GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Rat hippocampal neurons
Concentration: 0.1 µM, 1 µM, 10 µM
Incubation Time: 1 hour
Result: Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.
In Vivo

GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (200-300 g and 300–350 g)[3]
Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg
Administration: Oral gavage
Result: Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.
Clinical Trial
Molecular Weight

275.27

Formula

C₁₃H₁₆F₃NO₂

CAS No.

202402-01-5

SMILES

O=C(NCC1=CC=C(C(F)(F)F)C=C1)CCCOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GET73GET 73GET-73OthersmGluR5γ-hydroxybutyric acidGHB anti-alcoholanxiolyticneuroprotectiveglutamateInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GET73
Cat. No.:
HY-108034
Quantity:
MCE Japan Authorized Agent: