1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. FAAH
  3. JNJ-1661010

JNJ-1661010 (Synonyms: Takeda-25)

Cat. No.: HY-N7062 Purity: 98.99%
Handling Instructions

JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics.

For research use only. We do not sell to patients.

JNJ-1661010 Chemical Structure

JNJ-1661010 Chemical Structure

CAS No. : 681136-29-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics[1][2].

IC50 & Target

IC50: 34 nM (rat FAAH) and 33 nM (human FAAH)[1]

In Vivo

JNJ-1661010 (Takeda-25; i.p.; 50 mg/kg) diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model[2].
JNJ-1661010 (i.p.; 10 mg/kg) has a T1/2 of 35 mins, a CL of 0.032 mL/min/kg, and a Cmax of 1.58 μM for rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

365.45

Formula

C₁₉H₁₉N₅OS

CAS No.
SMILES

O=C(NC1=CC=CC=C1)N(CC2)CCN2C3=NC(C4=CC=CC=C4)=NS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (273.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7364 mL 13.6818 mL 27.3635 mL
5 mM 0.5473 mL 2.7364 mL 5.4727 mL
10 mM 0.2736 mL 1.3682 mL 2.7364 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

JNJ-1661010Takeda-25JNJ1661010JNJ 1661010Takeda25Takeda 25FAAHFatty acid amide hydrolaseFattyacidamidehydrolaseblood-brainbarrierbroad-spectrumanalgesicsInhibitorinhibitorinhibit

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Product Name:
JNJ-1661010
Cat. No.:
HY-N7062
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