1. Metabolic Enzyme/Protease
    Apoptosis
  2. Stearoyl-CoA Desaturase (SCD)
    Apoptosis
  3. CVT-11127

CVT-11127 (Synonyms: GS-456332)

Cat. No.: HY-113638
Handling Instructions

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CVT-11127 Chemical Structure

CVT-11127 Chemical Structure

CAS No. : 1018674-83-3

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Description

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

IC50 & Target

SCD[1]

In Vitro

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Showed antiproliferation activity.

Cell Cycle Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 24 h
Result: Induced apoposis H460 cells.
Molecular Weight

512.39

Formula

C25H23Cl2N5O3

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CVT-11127
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