CVT-11127
Based on 1 Customer Validation
CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 1018674-83-3
- Formula: C25H23Cl2N5O3
- Molecular Weight:512.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Lung Cancer Compound Library
HY-L075
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Anti-Cancer Metabolism Compound Library
HY-L083
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Anti-Obesity Compound Library
HY-L087
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Lipid Metabolism Compound Library
HY-L091
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Peptide Library
HY-L105
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Peptide Compound Library
HY-L105S
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
SCD[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
81 nM
Compound: 6a
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Inhibition of Delta-9-desaturase in human HepG2 cells
Inhibition of Delta-9-desaturase in human HepG2 cells
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[PMID: 19249203] |
CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H460 cells
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Concentration:1 µM
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Incubation Time:48 h
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Result:Showed antiproliferation activity.
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Cell Line:H460 cells
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Concentration:1 µM
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Incubation Time:48 h
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Result:Decreased the the population of cells in S-phase by 75%.
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Cell Line:H460 cells
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Concentration:1 µM
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Incubation Time:24 h
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Result:Induced apoposis H460 cells.
Chemical Information
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CAS No. 1018674-83-3
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Appearance Solid
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Molecular Weight 512.39
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Formula C25H23Cl2N5O3
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Color Light yellow to yellow
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Synonyms
GS-456332
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (48.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9516 mL | 9.7582 mL | 19.5164 mL | 48.7910 mL |
| 5 mM | 0.3903 mL | 1.9516 mL | 3.9033 mL | 9.7582 mL | |
| 10 mM | 0.1952 mL | 0.9758 mL | 1.9516 mL | 4.8791 mL | |
| 15 mM | 0.1301 mL | 0.6505 mL | 1.3011 mL | 3.2527 mL | |
| 20 mM | 0.0976 mL | 0.4879 mL | 0.9758 mL | 2.4395 mL | |
| 25 mM | 0.0781 mL | 0.3903 mL | 0.7807 mL | 1.9516 mL | |
| 30 mM | 0.0651 mL | 0.3253 mL | 0.6505 mL | 1.6264 mL | |
| 40 mM | 0.0488 mL | 0.2440 mL | 0.4879 mL | 1.2198 mL |
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