Palmitic acid sodium

Name: Palmitic acid sodium
Brand: MedChemExpress
SKU: HY-N0830B
Rating: 5.0 (100 reviews)

Cat. No.: HY-N0830B Purity: 95.0%: Data Sheet
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Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

For research use only. We do not sell to patients.

CAS No. : 408-35-5

Size	Stock	Quantity
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Based on 100 publication(s) in Google Scholar

Other Forms of Palmitic acid sodium:

Palmitic acid-¹³C sodium In-stock
Palmitic acid-¹³C₁₆ sodium In-stock
Palmitic acid-d₃₁ sodium In-stock
Palmitic acid-1,2,3,4-¹³C₄ In-stock
Palmitic acid-¹³C₂ In-stock
Palmitic acid-d₃₁ In-stock
Palmitic acid-1-¹³C In-stock
Palmitic acid-d₂ In-stock
Palmitic acid-d₃ In-stock
Palmitic acid-¹³C₁₆ In-stock
Palmitic acid-d₄ In-stock
Palmitic acid-¹³C In-stock
Palmitic acid In-stock
Palmitic acid-d₃ sodium Get quote
Palmitic acid-15,15,16,16,16-d₅ Get quote
Palmitic acid-d₂-1 Get quote
Palmitic acid-9,10-d₂ Get quote
Palmitic acid calcium Get quote

100 Publications Citing Use of MCE Palmitic acid sodium

Flow Cytometry

Cell Imaging/Staining

Cell Proliferation/Viability Assay

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528. [Abstract]; OVCAR8 and A2780 cells were cultured in fatty acid-free media supplemented with 50 μM AA (arachidonic acid), 50 μM OA (oleic acid), 50 μM EPA (eicosapentaenoic acid), 50 μM PA (Palmitic acid), and 50 μM MA (myristic acid) with the treatment of 10 μM niraparib for 72 h, and the cell viability was determined.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jan;21(1):178-190. [Abstract]; Sqstm1^−/− MEFs reconstituted with vector, flag-SQSTM1 WT, or Flag-SQSTM1^K7R were treated with BSA or Palmitic acid (PA) (500 μM) for 12 h. Cell lysates were mixed with loading buffer containing or not containing DTT were subjected to SDS-PAGE and IB.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]; Cell viability was assessed using CCK-8 assay in MIN6 cells treated with 33.3 mM glucose and varying concentrations of palmitic acid (PA; 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, and 0.8 mM) for 24 h.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]; FACS plots and quantification of Annexin-V+/PI + population percentage, indicative of apoptotic cells, were analyzed in controls and HGP-treated cells. MIN6 cells with HGP(33.3 mM glucose and 0.3 mM Palmitic acid sodium) for 24 h, cell survival remained around 80 %.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]; Immunoblot and quantification of p16, p21, and p-γH2A.X in HGP-treated MIN6 cells. The β-actin blot was used as a protein loading control. MIN6 cells treated with high glucose and palmitic acid (HGP; 33.3 mM glucose and 0.3 mM palmitic acid sodium) for 24 h.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]; Representative images and quantification of SA-β-gal staining in MIN6 cells. MIN6 cells were treated with high glucose and palmitic acid (HGP; 33.3 mM glucose and 0.3 mM Palmitic acid sodium) for 24 h.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]; Representative images of nuclear morphological changes observed via DAPI staining. MIN6 cells were treated with high glucose and palmitic acid (HGP; 33.3 mM glucose and 0.3 mM Palmitic acid sodium) for 24 h.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 9:33:85-99.; The expression of NLRP3 and GSDMD was detected in PDLCs treated with palmitic acid (PA) (300 μM; 24 h).

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26. [Abstract]; Palmitic acid (PA; 20 or 100 μM; 24 h) rescues ACOX1-mediated β-catenin inhibition in HCT15 cells (transfected with Flag-ACOX1 plasmid).

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26. [Abstract]; Palmitic acid (PA; 50, 100, 200 μM; 24 h) decreases endogenous β-catenin polyubiquitination in a dose-dependent manner, in HEK293T cells.

: Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26. [Abstract]; Palmitic acid (PA; 100 μM; 24 h) suppresses the interactions between β-catenin and CK1, GSK3, and β-TrCP in HEK293T cells (transfected with Flag-CK1 and Flag-GSK3β).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Grp78

In Vitro

Palmitic acid sodium (0.1, 0.25 or 0.5 mM; 12-72 h) increases the mRNA levels of Notch1, 2 and 4 in LX2, Huh7 and MIHA hepatic cell lines. Palmitic acid sodium is dissolved in DMEM containing 1% BSA and filtered through a 0.22-μm filter, then added to the cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

278.41

Formula

C₁₆H₃₁NaO₂

CAS No.

408-35-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCCCCCCCCCCC)O[Na]

Initial Source

Widespread

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL (29.92 mM; ultrasonic and warming and adjust pH to 4 with 1M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5918 mL	17.9591 mL	35.9182 mL
5 mM	0.7184 mL	3.5918 mL	7.1837 mL
10 mM	0.3592 mL	1.7959 mL	3.5918 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.11 mg/mL (3.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.11 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (11.1 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (239 KB) IR (204 KB)

Handling Instructions (2659 KB)

References

[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90. [Content Brief]

[2]. Wen-Jin Ding, et al. Expression of Notch family is altered in non‑alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5918 mL	17.9591 mL	35.9182 mL	89.7956 mL
	5 mM	0.7184 mL	3.5918 mL	7.1836 mL	17.9591 mL
	10 mM	0.3592 mL	1.7959 mL	3.5918 mL	8.9796 mL
	15 mM	0.2395 mL	1.1973 mL	2.3945 mL	5.9864 mL
	20 mM	0.1796 mL	0.8980 mL	1.7959 mL	4.4898 mL
	25 mM	0.1437 mL	0.7184 mL	1.4367 mL	3.5918 mL