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  3. Palmitic acid sodium

Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

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Palmitic acid sodium Chemical Structure

Palmitic acid sodium Chemical Structure

CAS No. : 408-35-5

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Customer Review

Based on 39 publication(s) in Google Scholar

Top Publications Citing Use of Products

36 Publications Citing Use of MCE Palmitic acid sodium

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    Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26.  [Abstract]

    Palmitic acid (PA; 20 or 100 μM; 24 h) rescues ACOX1-mediated β-catenin inhibition in HCT15 cells (transfected with Flag-ACOX1 plasmid).

    Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26.  [Abstract]

    Palmitic acid (PA; 100 μM; 24 h) suppresses the interactions between β-catenin and CK1, GSK3, and β-TrCP in HEK293T cells (transfected with Flag-CK1 and Flag-GSK3β).

    Palmitic acid sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26.  [Abstract]

    Palmitic acid (PA; 50, 100, 200 μM; 24 h) decreases endogenous β-catenin polyubiquitination in a dose-dependent manner, in HEK293T cells.

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    • Biological Activity

    • Purity & Documentation

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    Description

    Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model [1][2].

    In Vitro

    Palmitic acid sodium (0.1, 0.25 or 0.5 mM; 12-72 h) increases the mRNA levels of Notch1, ?2 and ?4 in LX2, Huh7 and MIHA hepatic cell lines. Palmitic acid sodium is dissolved in DMEM containing 1% BSA and filtered through a 0.22-μm filter, then added to the cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    278.41

    Formula

    C16H31NaO2

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(CCCCCCCCCCCCCCC)O[Na]

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 8.33 mg/mL (29.92 mM; ultrasonic and warming and adjust pH to 4 with 1M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5918 mL 17.9591 mL 35.9182 mL
    5 mM 0.7184 mL 3.5918 mL 7.1837 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.11 mg/mL (3.99 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.11 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (11.1 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: ≥95.0%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.5918 mL 17.9591 mL 35.9182 mL 89.7956 mL
    5 mM 0.7184 mL 3.5918 mL 7.1836 mL 17.9591 mL
    10 mM 0.3592 mL 1.7959 mL 3.5918 mL 8.9796 mL
    15 mM 0.2395 mL 1.1973 mL 2.3945 mL 5.9864 mL
    20 mM 0.1796 mL 0.8980 mL 1.7959 mL 4.4898 mL
    25 mM 0.1437 mL 0.7184 mL 1.4367 mL 3.5918 mL
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Palmitic acid sodium
    Cat. No.:
    HY-N0830B
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