Palmitic acid calcium
Based on 115 publication(s) in Google Scholar
Palmitic acid calcium is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid calcium is used to establish a cell steatosis model.
For research use only. We do not sell to patients.
- CAS No.: 542-42-7
- Formula: C16H32O2.1/2Ca
- Molecular Weight:275.46
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Publications Citing Use of MedChemExpress (MCE) Palmitic acid calcium
More- Signal Transduct Target Ther. 2025 Dec 3;10(1):394. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Science. 2025 Mar 14;387(6739):eadm9805. [Abstract]
- Bioact Mater. 2023 Nov 9:33:85-99. [Abstract]
- Nat Microbiol. 2026 Jun;11(6):1677-1695. [Abstract]
- Autophagy. 2025 Jun 7:1-19. [Abstract]
- Autophagy. 2025 Jan;21(1):178-190. [Abstract]
- Adv Sci (Weinh). 2026 Jun;13(35):e21458. [Abstract]
- Adv Sci (Weinh). 2023 Oct;10(28):e2302130. [Abstract]
- Cell Discov. 2023 Mar 7;9(1):26. [Abstract]
- Metabolism. 2026 Jun 7:182:156670. [Abstract]
- Redox Biol. 2025 Feb 3:80:103528. [Abstract]
- Gut Microbes. 2022 Jan-Dec;14(1):2139978. [Abstract]
- Cell Rep Med. 2025 Aug 19;6(8):102260. [Abstract]
- Cardiovasc Diabetol. 2023 May 6;22(1):107. [Abstract]
- J Neuroinflammation. 2021 Jul 18;18(1):159. [Abstract]
- Cell Death Dis. 2026 Feb 5;17(1):205. [Abstract]
- Burns Trauma. 2026 Jan 13.
- Cell Death Dis. 2024 Jun 12;15(6):411. [Abstract]
- Cell Death Dis. 2019 May 28;10(6):416. [Abstract]
- Genes Dis. 2026 Mar 19.
- Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2504904123. [Abstract]
- Cell Commun Signal. 2026 May 7. [Abstract]
- J Pharm Anal. 2025 Dec;15(12):101307. [Abstract]
- Int J Biol Macromol. 2026 Mar:350:150930. [Abstract]
- Phytomedicine. 2025 Jul:142:156777. [Abstract]
- Phytomedicine. 2024 Jan:123:155209. [Abstract]
- Free Radic Biol Med. 2026 Aug 16:252:664-676. [Abstract]
- Free Radic Biol Med. 2025 Dec 18:S0891-5849(25)01443-1. [Abstract]
- Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]
- Free Radic Biol Med. 2023 Jun:202:110-120. [Abstract]
- Biomed Pharmacother. 2024 Jul 6:177:117085. [Abstract]
- Chin Med J (Engl). 2026 Mar 16. [Abstract]
- Cell Death Discov. 2026 Apr 13;12(1):227. [Abstract]
- Cell Rep. 2026 Feb 18;45(3):116993. [Abstract]
- Cell Rep. 2025 Nov 25;44(11):116496. [Abstract]
- Cell Rep. 2025 Feb 25;44(3):115350. [Abstract]
- Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]
- Phytother Res. 2023 Dec;37(12):5991-6005. [Abstract]
- Phytother Res. 2022 Jan;36(1):433-447. [Abstract]
- Cell Biol Toxicol. 2024 Nov 26;40(1):104. [Abstract]
- eFood. 2025 Jun 30.
- Acta Neuropathol Commun. 2025 Apr 25;13(1):84. [Abstract]
- Biochem Pharmacol. 2026 Mar 22:249:117926. [Abstract]
- J Ethnopharmacol. 2026 Feb 28:357:120941. [Abstract]
- J Ethnopharmacol. 2025 Jul 29:120333. [Abstract]
- J Ethnopharmacol. 2024 Nov 26:339:119162. [Abstract]
- J Ethnopharmacol. 2024 Mar 1:321:117550. [Abstract]
- Food Funct. 2022 May 23;13(10):5559-5570. [Abstract]
- Food Funct. 2021 Dec 13;12(24):12421-12433. [Abstract]
- Life Sci. 2026 Jul 15:397:124392. [Abstract]
- Life Sci. 2025 May 5:374:123687. [Abstract]
- J Nutr Biochem. 2026 Sep:155:110381. [Abstract]
- Front Pharmacol. 2024 Oct 23:15:1496639. [Abstract]
- Front Pharmacol. 2022 Jun 30;13:920601. [Abstract]
- Int Immunopharmacol. 2024 Oct 11;143(Pt 1):113327. [Abstract]
- mBio. 2024 Jul 2:e0154924. [Abstract]
- RSC Adv. 2025 Nov 27;15(55):46775-46789. [Abstract]
- J Med Virol. 2025 Nov;97(11):e70699. [Abstract]
- Probiotics Antimicrob Proteins. 2025 May 14. [Abstract]
- J Integr Agric. 2024 May 13.
- ACS Omega. 2024 Feb 28;9(10):11870-11882. [Abstract]
- J Physiol Biochem. 2024 May;80(2):407-420. [Abstract]
- FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Mar 31;1870(5):167142. [Abstract]
- Mol Nutr Food Res. 2023 Apr;67(7):e2101052. [Abstract]
- Mol Nutr Food Res. 2023 Jan;67(2):e2200429. [Abstract]
- iScience. 2026 Mar 25;29(4):115470. [Abstract]
- Aquaculture. 2026 May 7;623:744131.
- Sci Rep. 2025 Mar 5;15(1):7768. [Abstract]
- Aquaculture. 15 January 2022, 737333.
- Food Sci Nutr. 2026 Apr 3;14(4):e71695. [Abstract]
- Int J Obes. 2025 Jul 28. [Abstract]
- J Virol. 2021 Aug 10;95(17):e0078121. [Abstract]
- Cell Signal. 2026 Apr:140:112360. [Abstract]
- Mater Technol (N Y N Y). 2025 Jun 17.
- Cell Signal. 2024 Nov 25:111528. [Abstract]
- World J Stem Cells. 2026 Mar 26;18(3).
- Biol Trace Elem Res. 2025 Jun 13. [Abstract]
- Heliyon. 2024 May 16;10(10):e30708. [Abstract]
- Vet Res. 2026 May 9;57(1):72. [Abstract]
- Biology (Basel). 2026 Jan 26;15(3):233. [Abstract]
- Mol Med Rep. 2020 Sep;22(3):1702-1708. [Abstract]
- BMC Cancer. 2025 May 28;25(1):956. [Abstract]
- Appl Biochem Biotechnol. 2026 Jun 10. [Abstract]
- BMC Endocr Disord. 2025 Feb 27;25(1):54. [Abstract]
- Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158540. [Abstract]
- Mol Immunol. 2026 May:193:91-102. [Abstract]
- Diabetes Metab Syndr Obes. 2021 Oct 2;14:4165-4177. [Abstract]
- Med Gas Res. 2025 Sep 1;15(3):374-382. [Abstract]
- Med Gas Res. 2025 Mar 1;15(1):148-155. [Abstract]
- Mol Biol Rep. 2026 May 25;53(1):821. [Abstract]
- Immun Inflamm Dis. 2026 Mar 9;14(3):e70395.
- PLoS One. 2025 Jul 14;20(7):e0328345. [Abstract]
- Tissue Cell. 2026 Feb 17:101:103399. [Abstract]
- Cell Biochem Biophys. 2025 Jul 28. [Abstract]
- Tissue Cell. 2025 May 20:96:102984. [Abstract]
- Plant Pathol. 2025 Dec 30.
- Biochem Biophys Res Commun. 2026 May 26;827:154019. [Abstract]
- Biochem Biophys Res Commun. 2026 Mar 12:804:153358. [Abstract]
- Sex Med. 2025 Aug 6;13(4):qfaf059. [Abstract]
- Sex Med. 2023 Jan 24;11(1):qfac008. [Abstract]
- Eur J Lipid Sci Technol. 2023 Feb 25.
- Xenobiotica. 2025 Sep 18:1-9. [Abstract]
- Curr Sci. 2025 Oct 8.
- Res Sq. 2026 May 21.
- Res Sq. 2026 Jan 15.
- CICESE. 2025.
- SSRN. 2025 May 22.
- bioRxiv. 2024 October 29.
- Research Square Preprint. 2024 Feb 19.
- Research Square Preprint. 2024 Feb 15.
- Research Square Preprint. 2023 Jul 20.
- Oxid Med Cell Longev. 2022 May 14;2022:3861380. [Abstract]
- Curr Top Nutraceutical Res. 2022 May 4.
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Biological Activity
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Grp78 |
Human Endogenous Metabolite |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 542-42-7
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Molecular Weight 275.46
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Formula C16H32O2.1/2Ca
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SMILES
CCCCCCCCCCCCCCCC([O-])=O.[Ca+2].[0.5]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (115)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2025 Dec 3;10(1):394. PMID: 41330906 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Science
2025 Mar 14;387(6739):eadm9805. PMID: 40080571 -
Bioact Mater
Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus. [Abstract]2023 Nov 9:33:85-99. PMID: 38024229
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 9:33:85-99. [Abstract]
The expression of NLRP3 and GSDMD was detected in PDLCs treated with palmitic acid (PA) (300 μM; 24 h).
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Nat Microbiol
Lipid accumulation in tuberculosis granulomas inhibits macrophage-CD4+ T cell interactions and infection control. [Abstract]2026 Jun;11(6):1677-1695. PMID: 41933199 -
Autophagy
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity. [Abstract]2025 Jun 7:1-19. PMID: 40437698 -
Autophagy
TRIM21-mediated ubiquitination of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity. [Abstract]2025 Jan;21(1):178-190. PMID: 39172027
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jan;21(1):178-190. [Abstract]
Sqstm1−/− MEFs reconstituted with vector, flag-SQSTM1 WT, or Flag-SQSTM1K7R were treated with BSA or Palmitic acid (PA) (500 μM) for 12 h. Cell lysates were mixed with loading buffer containing or not containing DTT were subjected to SDS-PAGE and IB.
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Adv Sci (Weinh)
Extracellular Vesicle-Transferred ATP-Citrate Lyase Induces Monocyte Differentiation Toward Tumor-Associated Macrophages and Fuels Hepatocellular Carcinoma Progression. [Abstract]2026 Jun;13(35):e21458. PMID: 41995119 -
Adv Sci (Weinh)
Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. [Abstract]2023 Oct;10(28):e2302130. PMID: 37544908 -
Cell Discov
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression. [Abstract]2023 Mar 7;9(1):26. PMID: 36878899
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26. [Abstract]
Palmitic acid (PA; 20 or 100 μM; 24 h) rescues ACOX1-mediated β-catenin inhibition in HCT15 cells (transfected with Flag-ACOX1 plasmid).
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26. [Abstract]
Palmitic acid (PA; 50, 100, 200 μM; 24 h) decreases endogenous β-catenin polyubiquitination in a dose-dependent manner, in HEK293T cells.
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2023 Mar 7;9(1):26. [Abstract]
Palmitic acid (PA; 100 μM; 24 h) suppresses the interactions between β-catenin and CK1, GSK3, and β-TrCP in HEK293T cells (transfected with Flag-CK1 and Flag-GSK3β).
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Metabolism
Acacetin ameliorates MASLD by inhibiting the Notch1 pathway in hepatocytes and reprogramming macrophage polarization via Keap1-Nrf2-mediated restraint of ferroptosis. [Abstract]2026 Jun 7:182:156670. PMID: 42259496 -
Redox Biol
Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis. [Abstract]2025 Feb 3:80:103528. PMID: 39922130
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528. [Abstract]
OVCAR8 and A2780 cells were cultured in fatty acid-free media supplemented with 50 μM AA (arachidonic acid), 50 μM OA (oleic acid), 50 μM EPA (eicosapentaenoic acid), 50 μM PA (Palmitic acid), and 50 μM MA (myristic acid) with the treatment of 10 μM niraparib for 72 h, and the cell viability was determined.
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Gut Microbes
FABP4 in Paneth cells regulates antimicrobial protein expression to reprogram gut microbiota. [Abstract]2022 Jan-Dec;14(1):2139978. PMID: 36519446 -
Cell Rep Med
High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis. [Abstract]2025 Aug 19;6(8):102260. PMID: 40749683 -
Cardiovasc Diabetol
Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X. [Abstract]2023 May 6;22(1):107. PMID: 37149668 -
J Neuroinflammation
C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation. [Abstract]2021 Jul 18;18(1):159. PMID: 34275474 -
Cell Death Dis
2026 Feb 5;17(1):205. PMID: 41644513 -
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Cell Death Dis
MAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing. [Abstract]2024 Jun 12;15(6):411. PMID: 38866777 -
Cell Death Dis
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?. [Abstract]2019 May 28;10(6):416. PMID: 31138790 -
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Proc Natl Acad Sci U S A
Circular RNA-based therapy targeting metabolic vulnerability of fatty acid synthesis overcomes castration-resistant prostate cancer. [Abstract]2026 Jan 6;123(1):e2504904123. PMID: 41468427 -
Cell Commun Signal
Paternal Sertoli cell-derived extracellular vesicles transfer mtDNA and microRNA cargo to trigger germ cell oxidative stress and induce metabolic risks in offspring. [Abstract]2026 May 7. PMID: 42098702 -
J Pharm Anal
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro. [Abstract]2025 Dec;15(12):101307. PMID: 41492461 -
Int J Biol Macromol
The CFP macromolecule attenuates senescent liver sinusoidal endothelial cell-driven activation of hepatic stellate cells. [Abstract]2026 Mar:350:150930. PMID: 41698486 -
Phytomedicine
Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome. [Abstract]2025 Jul:142:156777. PMID: 40393214 -
Phytomedicine
Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK/p300/SREBP-1c axis. [Abstract]2024 Jan:123:155209. PMID: 37984123 -
Free Radic Biol Med
Vitamin D receptor/sirtuin 3 pathway mediates the cardioprotective effects of aerobic exercise in diabetic mice. [Abstract]2026 Aug 16:252:664-676. PMID: 42061479 -
Free Radic Biol Med
PM2.5 exacerbate nonalcoholic fatty liver disease through activating hepatocytes TXNIP/NLRP3/FoxO1 signaling pathway in ob/ob mice. [Abstract]2025 Dec 18:S0891-5849(25)01443-1. PMID: 41421414 -
Free Radic Biol Med
AQP1 mediates pancreatic β cell senescence induced by metabolic stress through modulating intracellular H2O2 level. [Abstract]2025 Jan:226:171-184. PMID: 39551452
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]
Cell viability was assessed using CCK-8 assay in MIN6 cells treated with 33.3 mM glucose and varying concentrations of palmitic acid (PA; 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, and 0.8 mM) for 24 h.
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]
FACS plots and quantification of Annexin-V+/PI + population percentage, indicative of apoptotic cells, were analyzed in controls and HGP-treated cells. MIN6 cells with HGP(33.3 mM glucose and 0.3 mM Palmitic acid sodium) for 24 h, cell survival remained around 80 %.
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]
Immunoblot and quantification of p16, p21, and p-γH2A.X in HGP-treated MIN6 cells. The β-actin blot was used as a protein loading control. MIN6 cells treated with high glucose and palmitic acid (HGP; 33.3 mM glucose and 0.3 mM palmitic acid sodium) for 24 h.
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]
Representative images and quantification of SA-β-gal staining in MIN6 cells. MIN6 cells were treated with high glucose and palmitic acid (HGP; 33.3 mM glucose and 0.3 mM Palmitic acid sodium) for 24 h.
Palmitic acid calcium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Jan:226:171-184. [Abstract]
Representative images of nuclear morphological changes observed via DAPI staining. MIN6 cells were treated with high glucose and palmitic acid (HGP; 33.3 mM glucose and 0.3 mM Palmitic acid sodium) for 24 h.
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Free Radic Biol Med
Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma. [Abstract]2023 Jun:202:110-120. PMID: 36997100 -
Biomed Pharmacother
1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2. [Abstract]2024 Jul 6:177:117085. PMID: 38972150 -
Chin Med J (Engl)
Effect of circulating exosomal miRNA-122-3p on metabolic dysfunction-associated steatotic liver disease through impairing FGFR4 expression. [Abstract]2026 Mar 16. PMID: 41839758 -
Cell Death Discov
Oncoprotein CYB561, acting in IRE1-XBP1-SREBF1 and FAK-ERK pathway, promotes breast cancer lipogenesis and progression. [Abstract]2026 Apr 13;12(1):227. PMID: 41974658 -
Cell Rep
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis. [Abstract]2026 Feb 18;45(3):116993. PMID: 41719123 -
Cell Rep
A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]2025 Nov 25;44(11):116496. PMID: 41166305 -
Cell Rep
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD. [Abstract]2025 Feb 25;44(3):115350. PMID: 40014451 -
Cell Rep
ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. [Abstract]2024 Nov 9;43(11):114962. PMID: 39522165 -
Phytother Res
Isorhynchophylline improves lipid metabolism disorder by mediating a circadian rhythm gene Bmal1 in spontaneously hypertensive rat. [Abstract]2023 Dec;37(12):5991-6005. PMID: 37752617 -
Phytother Res
Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway. [Abstract]2022 Jan;36(1):433-447. PMID: 34859513 -
Cell Biol Toxicol
Protocatechuic acid relieves ferroptosis in hepatic lipotoxicity and steatosis via regulating NRF2 signaling pathway. [Abstract]2024 Nov 26;40(1):104. PMID: 39589556 -
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Acta Neuropathol Commun
Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance. [Abstract]2025 Apr 25;13(1):84. PMID: 40281543 -
Biochem Pharmacol
Propyl gallate mitigates diabetic liver injury via suppressing SLC7A11/GPX4-mediated hepatic ferroptosis and modulating gut-liver axis. [Abstract]2026 Mar 22:249:117926. PMID: 41876017 -
J Ethnopharmacol
Shentong Zhuyu Decoction mitigates exercise-induced muscle damage through modulation of AMPK-mediated lipid metabolism and oxidative stress. [Abstract]2026 Feb 28:357:120941. PMID: 41270908 -
J Ethnopharmacol
Licochalcone A promotes autophagy to ameliorate NAFLD by inhibiting the mTOR and regulating ULK1/Beclin1/VPS34 pathway. [Abstract]2025 Jul 29:120333. PMID: 40744422 -
J Ethnopharmacol
Kaempferol modulates ɑ2M secretion in bone marrow-derived macrophages by downregulating GR/PER1-mediated lipid metabolism to attenuate the emotional stress-aggravated metastasis of prostate cancer. [Abstract]2024 Nov 26:339:119162. PMID: 39603396 -
J Ethnopharmacol
Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study. [Abstract]2024 Mar 1:321:117550. PMID: 38065350 -
Food Funct
2022 May 23;13(10):5559-5570. PMID: 35481558 -
Food Funct
Phloretin attenuation of hepatic steatosis via an improvement of mitochondrial dysfunction by activating AMPK-dependent signaling pathways in C57BL/6J mice and HepG2 cells. [Abstract]2021 Dec 13;12(24):12421-12433. PMID: 34788781 -
Life Sci
G0S2 drives lipid metabolism disorders and oxidative stress to promote M1 macrophage polarization and inflammation in polycystic ovary syndrome. [Abstract]2026 Jul 15:397:124392. PMID: 41985712 -
Life Sci
GSK621 ameliorates lipid accumulation via AMPK pathways and reduces oxidative stress in hepatocytes in vitro and in obese mice in vivo. [Abstract]2025 May 5:374:123687. PMID: 40334907 -
J Nutr Biochem
Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2. [Abstract]2026 Sep:155:110381. PMID: 41997457 -
Front Pharmacol
Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond. [Abstract]2024 Oct 23:15:1496639. PMID: 39508046 -
Front Pharmacol
Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway. [Abstract]2022 Jun 30;13:920601. PMID: 35846993 -
Int Immunopharmacol
METTL3-mediated m6A modification of CD36: Implications for glucose metabolism and inflammatory dysregulation in follicles of polycystic ovary syndrome. [Abstract]2024 Oct 11;143(Pt 1):113327. PMID: 39395382 -
mBio
2024 Jul 2:e0154924. PMID: 38953350 -
RSC Adv
Polymer-lipid hybrid nanoparticles incorporating green coffee extract: enhancing treatment for hepatic steatosis and fibrosis through metabolomic insights. [Abstract]2025 Nov 27;15(55):46775-46789. PMID: 41323711 -
J Med Virol
HPV16 Enhances Radiosensitivity in Esophageal Squamous Cell Carcinoma by Promoting De Novo Fatty Acid Synthesis and Disulfidptosis. [Abstract]2025 Nov;97(11):e70699. PMID: 41231234 -
Probiotics Antimicrob Proteins
Lactobacillus rhamnosus GG Supernatant Improves GLP-1 Secretion Through Attenuating L Cell Lipotoxicity and Modulating Gut Microbiota in Obesity. [Abstract]2025 May 14. PMID: 40366615 -
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ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939 -
J Physiol Biochem
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition. [Abstract]2024 May;80(2):407-420. PMID: 38492180 -
FASEB J
SREBP-1-mediated lipogenesis confers resistance to ferroptosis and improves endothelial injury. [Abstract]2024 Jul 15;38(13):e23806. PMID: 38970404 -
Biochim Biophys Acta Mol Basis Dis
Rabeprazole mitigates obesity-induced chronic inflammation and insulin resistance associated with increased M2-type macrophage polarization. [Abstract]2024 Mar 31;1870(5):167142. PMID: 38565384 -
Mol Nutr Food Res
Oxidative Stress Mediated by N6-Methyladenosine Methylation Contributes to High-Fat Diet Induced Male Reproductive Dysfunction. [Abstract]2023 Apr;67(7):e2101052. PMID: 36738079 -
Mol Nutr Food Res
Consumption of Saturated Fatty Acids-Rich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR-γ. [Abstract]2023 Jan;67(2):e2200429. PMID: 36433679 -
iScience
Iturin derived from Bacillus modulates lipid and glucose metabolism while mitigating the progression of MASLD. [Abstract]2026 Mar 25;29(4):115470. PMID: 41993687 -
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Sci Rep
Metformin hydrochloride improves hepatic glucolipid metabolism in diabetes progression through SIRT5-mediated ECHA desuccinylation. [Abstract]2025 Mar 5;15(1):7768. PMID: 40044936 -
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Food Sci Nutr
Integrative Network Pharmacology, Molecular Docking, and In Vitro Insights Into the Mechanism of Finger Citron for Non-Alcoholic Fatty Liver Disease. [Abstract]2026 Apr 3;14(4):e71695. PMID: 41948376 -
Int J Obes
Agomelatine alleviates palmitic acid-induced mouse oocyte meiosis defects by restoring mitochondrial function. [Abstract]2025 Jul 28. PMID: 40721860 -
J Virol
Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B. [Abstract]2021 Aug 10;95(17):e0078121. PMID: 34132567 -
Cell Signal
Ophiopogonis japonicus polysaccharide inhibits oxidative stress in hepatocytes by promoting Runx3 in nonalcoholic fatty liver disease. [Abstract]2026 Apr:140:112360. PMID: 41520744 -
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Cell Signal
METRNL exerts cytoprotective effects on EPCs via regulation of the E2F1-TXNIP axis in obese limb ischemia. [Abstract]2024 Nov 25:111528. PMID: 39603439 -
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Biol Trace Elem Res
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation. [Abstract]2025 Jun 13. PMID: 40512369 -
Heliyon
Chronotherapy involving rosiglitazone regulates the phenotypic switch of vascular smooth muscle cells by shifting the phase of TNF-α rhythm through triglyceride accumulation in macrophages. [Abstract]2024 May 16;10(10):e30708. PMID: 38803898 -
Vet Res
2026 May 9;57(1):72. PMID: 42106845 -
Biology (Basel)
Targeting GPR68 Alleviates Inflammation and Lipid Accumulation in Metabolic Dysfunction-Associated Steatohepatitis. [Abstract]2026 Jan 26;15(3):233. PMID: 41677704 -
Mol Med Rep
2020 Sep;22(3):1702-1708. PMID: 32705262 -
BMC Cancer
TRPM2 channels mediate ROS-induced actin remodeling and cell migration of prostate cancer cells. [Abstract]2025 May 28;25(1):956. PMID: 40437388 -
Appl Biochem Biotechnol
Decreasing S1PR3 Alleviated Renal Tubular Lipid Deposition in Diabetic Nephropathy via AMPK/PPAR-γ/GPAT3 Pathway. [Abstract]2026 Jun 10. PMID: 42268342 -
BMC Endocr Disord
The predictive function of miR-122-5p and its action mechanism by regulating PKM2 in metabolic syndrome. [Abstract]2025 Feb 27;25(1):54. PMID: 40011864 -
Biochim Biophys Acta Mol Cell Biol Lipids
Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration. [Abstract]2020 Feb;1865(2):158540. PMID: 31678511 -
Mol Immunol
2026 May:193:91-102. PMID: 41855765 -
Diabetes Metab Syndr Obes
Ethyl 2-[2,3,4-Trimethoxy-6-(1-Octanoyl)Phenyl] Acetate (TMPA) Ameliorates Lipid Accumulation by Disturbing the Combination of LKB1 with Nur77 and Activating the AMPK Pathway in HepG2 Cells and Mice Primary Hepatocytes. [Abstract]2021 Oct 2;14:4165-4177. PMID: 34629883 -
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Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease. [Abstract]2025 Sep 1;15(3):374-382. PMID: 40251018 -
Med Gas Res
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Mol Biol Rep
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PLoS One
IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP. [Abstract]2025 Jul 14;20(7):e0328345. PMID: 40658677 -
Tissue Cell
Palmitic acid-evoked PKR/JNK activation and SIRT1 decline: Association with myocardial ageing phenotype changes and partial reversal by inhibitors. [Abstract]2026 Feb 17:101:103399. PMID: 41759332 -
Cell Biochem Biophys
FABP4 Downregulated by FOS Alleviates Palmitic Acid-induced Endothelial Cell Dysfunction Via Inactivating ERK/STAT-1 Signaling Pathway. [Abstract]2025 Jul 28. PMID: 40720074 -
Tissue Cell
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway. [Abstract]2025 May 20:96:102984. PMID: 40451044 -
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Sex Med
Hinokiflavone alleviates high-fat diet-induced erectile dysfunction via the EGFR/PI3K/Akt/eNOS signaling pathway. [Abstract]2025 Aug 6;13(4):qfaf059. PMID: 40808867 -
Sex Med
Transcriptome analysis highlights the role of ferroptosis in palmitic acid-induced endothelial dysfunction. [Abstract]2023 Jan 24;11(1):qfac008. PMID: 37056514 -
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Xenobiotica
Calycosin improves insulin resistance by regulating the hsa-miR-324-3p/AKT pathway to inhibit FOXO3a nuclear transfer. [Abstract]2025 Sep 18:1-9. PMID: 40924558 -
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Oxid Med Cell Longev
Yaobishu Regulates Inflammatory, Metabolic, Autophagic, and Apoptosis Pathways to Attenuate Lumbar Disc Herniation. [Abstract]2022 May 14;2022:3861380. PMID: 35615578 -
Purity & Documentation
References
[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90. [Content Brief]
[2]. Wen-Jin Ding, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Palmitic acid calcium Related Classifications
HY-N0830A Related Classifications
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