2. Apoptosis Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Neuronal Signaling TGF-beta/Smad Epigenetics
  3. TNF Receptor GLUT Proteasome Tau Protein PKC
  4. Punicic acid

Punicic acid  (Synonyms: Trichosanic acid)

Cat. No.: HY-139066 Purity: 98.5%
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Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways.

For research use only. We do not sell to patients.

Punicic acid

Punicic acid Chemical Structure

CAS No. : 544-72-9

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1 mg (35.92 mM * 100 μL in Methanol) In-stock

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Based on 1 publication(s) in Google Scholar

Punicic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Punicic acid

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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GLUT1 GLUT2 GLUT3 GLUT4

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

  • Biological Activity

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Description

Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
FaDu IC50
9 μM
Compound: Punicic acid
Cytotoxicity against human FaDu cells assessed as reduction in cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human FaDu cells assessed as reduction in cell growth measured after 24 hrs by MTT assay
[PMID: 38306267]
HCT-116 IC50
5 nM
Compound: Punicic acid
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 38306267]
HCT-116 IC50
5 μM
Compound: 60; Pun A
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by presto blue reagent based analysis
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by presto blue reagent based analysis
[PMID: 38142509]
T98G IC50
9.85 μL/ml
Compound: 161
Growth inhibition of human T98 GBM cells
Growth inhibition of human T98 GBM cells
[PMID: 35786935]
In Vitro

Punicic acid (10 μM, 4 min) inhibits TNF-α induced neutrophil ROS overproduction without affecting fMLP or PMA (HY-18739) induced responses[2].
Punicic acid (0-40 μM, 30 min) reduces TNF-α induced p47phox phosphorylation starting from 10 mM concentration[2].
Punicic acid (10 μM, 30 min) inhibits TNF-α induced NADPH oxidase activation[2].
Punicic acid (0-40 μM; 48 h) exhibits a concentration-dependent antiproliferative effect on MDA-ERα7 and MDA-wt cells[4].
Punicic acid (40 μM; 48 h) induces apoptosis of MDA-ERα7 and MDA-wt cells and increases the percentage of cells in the G2/M phase. The ability to induce apoptosis of MDA-ERα7 and MDA-wt cells is completely blocked in the presence of 20 μM α-tocotrienol (HY-129459)[4].
Punicic acid (5-80 μM; 48 h) is partially blocked in the presence of BIM (4 μM) on MDA-ERα7 and MDA-wt cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Punicic acid Related Antibodies

Western Blot Analysis[1]

Cell Line: Neutrophils
Concentration: 0, 10, 20, 40 µM
Incubation Time: 30 min
Result: Reduced TNFa-induced p47phox phosphorylation starting from 10 µM concentration.
Inhibited p38MAPK phosphorylation at 20 µM similarly to p47phox inhibition of Ser345 phosphorylation, but almost no phospho-Ser345 and phosphoP38MAPK were detected.

Apoptosis Analysis[4]

Cell Line: MDA-ERα7 and MDA-wt cells
Concentration: 40 µM
Incubation Time: 48 h
Result: The apoptosis rate of BRCA cells is 86-91%.

Cell Proliferation Assay[4]

Cell Line: MDA-ERα7 and MDA-wt cells
Concentration: 0-40 µM
Incubation Time: 48 h
Result: The proliferation rate of MDA-ERα7 was only 4.5%, while that of MDA-wt was 8.5% at a dose of 40 µM.

Cell Cycle Analysis[4]

Cell Line: MDA-ERα7 and MDA-wt cells
Concentration: 40 µM
Incubation Time: 48 h
Result: The percent of MDA-ERα7 cells in the G2/M phase increased from 27.3 to 41.3% and the percent of MDA-wt cells in the G2/M phase increased from 12.3 to 20.3%.
In Vivo

Punicic acid (400 μg, i.g.; once daily for ten days) reduces significantly the TNBS-induced colonic damage in male Wistar rats by demonstrating mild inflammatory infiltration accompanied by punctate mucosal erosions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TNBS-induced Colitis male Wistar rat[1]
Dosage: 400 μg
Administration: i.g.
Result: Reduced the hyperactivation of neutrophils in the colon of TNBS-treated rats and inhibited the release of MPO and ROS by neutrophils, thereby reducing lipid peroxidation and tissue damage.
Molecular Weight

278.43

Formula

C18H30O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCC/C=C\C=C\C=C/CCCCCCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 98.5%

SDS (419 KB)

COA (238 KB)

Handling Instructions (2659 KB)
References
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Punicic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Punicic acid544-72-9Trichosanic acidTNF ReceptorGLUTProteasomeTau ProteinPKCTumor Necrosis Factor ReceptorTNFRGlucose transporter Protein kinase Cbioactivepomegranate seed oilisomerα-linolenic acidfatty acidchronic diseaseInhibitorinhibitorinhibit

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