α-Eleostearic acid
Based on 1 Customer Validation
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity.
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 506-23-0
- Formula: C18H30O2
- Molecular Weight:278.43
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Storage:
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
α-Eleostearic acid (0-40 μM; 24 h) inhibits the growth of some cancer and fibroblast cell lines, including those of HL60 leukemia and HT29 colon carcinoma[1].
α-Eleostearic acid (20 μM; 6 h) induced cellular and nuclear fragmentation, and nucleosomal DNA fragmentation typical of apoptosis in HL60 leukemia cells[1].
α-Eleostearic acid (0.01-100 μM; 72 h) triggers death of MDA-MB-231 cells and this death was suppressed by Fer-1, Deferoxamine, and vitamin E[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Oral administration of tung oil, naturally rich inα-Eleostearic acid, to mice limits tumor growth and metastasis in an aggressive TNBC orthotopic xenograft model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 506-23-0
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Appearance Liquid
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Molecular Weight 278.43
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Formula C18H30O2
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Color Colorless to light yellow
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SMILES
CCCC/C=C/C=C/C=C\CCCCCCCC(O)=O
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Synonyms
cis-Eleostearic acid
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Purity & Documentation
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Data Sheet (263 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
[1]. Kobori M, et, al. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J Agric Food Chem. 2008 Nov 26;56(22):10515-20. [Content Brief]
[2]. Saha SS, et, al. Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite. Food Chem Toxicol. 2009 Oct;47(10):2551-6. [Content Brief]
[3]. Beatty A, et, al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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