2. Apoptosis
  3. Apoptosis
  4. Jacaric acid

Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator. Jacaric acid is orally active.

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Jacaric acid Chemical Structure

Jacaric acid Chemical Structure

CAS No. : 28872-28-8

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Jacaric acid Related Antibodies

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Description

Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator[3]. Jacaric acid is orally active.

In Vitro

Jacaric acid (0-10 μM) dose- and time-dependently induces apoptosis in cells PC-3 and LNCaP, through an intrinsic and an intrinsic and extrinsic pathway, respectively[1].
Jacaric acid (0-10 μM) induces cytotoxicity in DLD-1 cells through intracellular incorporation and induction of apoptosis via lipid peroxidation[2].
Jacaric acid (50-100 μM) activates the macrophage through secretion of cytokines IFN-γ, IL-1β and TNF-α, enhances the endocytic activity in murine peritoneal macrophages and induces the cytostatic activity in MBL-2 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Jacaric acid Related Antibodies

Western Blot Analysis[1]

Cell Line: PC-3, LNCaP
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Increased cleaved PARP and caspase 9 in PC-3 cells.
Increased cleaved PARP, caspase 8, caspase 9, p15 Bid and death receptor DR5 in LNCaP cells.

Apoptosis Analysis[1]

Cell Line: PC-3, LNCaP, DLD-1
Concentration: 0-10 μM
Incubation Time: 24 h for cells PC-3 and LNCaP, 12 h for cell DLD-1
Result: Induced apoptosis.
In Vivo

Jacaric acid (1 mg/day/mouse, p.o. for 36 days) exhibits antitumor activity in DLD-1 transplanted athymic nude mice, without significant toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DLD-1 xenograft athymic nude mice[2]
Dosage: 1 mg/mouse
Administration: p.o. for 36 days
Result: Reduced tumor volume without significant weight loss in body and liver.
Molecular Weight

278.43

Formula

C18H30O2
CAS No.
SMILES

CCCCC/C=C\C=C\C=C/CCCCCCC(O)=O
Structure Classification
Initial Source
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Storage

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Purity & Documentation
References
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Jacaric acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jacaric acid28872-28-8ApoptosisPC-3LNCaPDLD-1MBL-2BALB/c nude mouseprostate canceradenocarcinomaT cell lymphoma,Inhibitorinhibitorinhibit

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