28872-28-8
Chemical Structure
Jacaric acid
- CAS No.: 28872-28-8
- Formula:C18H30O2
- Molecular Weight:278.43
IUPAC Name: (8Z,10E,12Z)-octadeca-8,10,12-trienoic acid
InChIKey: DQGMPXYVZZCNDQ-KDQYYBQISA-N
SMILES: CCCCC/C=C\C=C\C=C/CCCCCCC(O)=O
Biological Activity: Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator[3]. Jacaric acid is orally active.
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Jacaric acid | Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator. Jacaric acid is orally active. | |||||||||||||||||||||
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- [1]. Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42.. [Content Brief]
- [2]. Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8. [Content Brief]
- [3]. Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684. [Content Brief]
Keywords
