(10E,12Z)-Octadeca-10,12-dienoic acid
Based on 1 publication(s) in Google Scholar
(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 2420-56-6
- Formula: C18H32O2
- Molecular Weight:280.45
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) (10E,12Z)-Octadeca-10,12-dienoic acid
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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PPARα |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
15 μM
Compound: 8
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Inhibition of CRM1 interaction with HIV1 HA-tagged Rev in HeLa cells assessed as inhibition of Rev nuclear export by indirect fluorescent antibody technique
Inhibition of CRM1 interaction with HIV1 HA-tagged Rev in HeLa cells assessed as inhibition of Rev nuclear export by indirect fluorescent antibody technique
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[PMID: 20176483] |
| SK-BR-3 | IC50 |
100 μM
Compound: 52, CLA
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Inhibition of FASN in human SKBR3 cells
Inhibition of FASN in human SKBR3 cells
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[PMID: 21726077] |
(10E,12Z)-Octadeca-10,12-dienoic acid (Compound trans-10, cis-12) (43.6 μM, 48 h) significantly reduces LPL activity, intracellular triacylglycerol and glycerol whist the glycerol release is significantly enhanced in 3T3-L1 adipocytes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
(10E,12Z)-Octadeca-10,12-dienoic acid (10 g/d, i.v. infusion, 5 d) leads to a linear decrease in milk fat synthesis until reaching a steady state after 3 days in dairy cows[4].
(10E,12Z)-Octadeca-10,12-dienoic acid (1 g/100 g, added to diet, 8 w) significantly reduces the NF-κB levels in the nuclear fraction of the mucosa and significantly elevates the cyclin D1 levels in C57BL/6J Min mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Holstein cows (536-584 kg)[4]
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Dosage:10 g/d
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Administration:Intravenous infusion
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Result:Decreased the milk fat synthesis.
Decreased the proportions of short- and medium-chain fatty acids in milk fat and increased proportions of long-chain fatty acids.
Affected mRNA abundance of lipogenic enzymes of the mammary gland.
Chemical Information
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CAS No. 2420-56-6
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Appearance Liquid
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Molecular Weight 280.45
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Formula C18H32O2
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C=C\CCCCCCCCC(O)=O
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Synonyms
trans-10,cis-12 CLA2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Animals (Basel)
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling. [Abstract]2025 Nov 26;15(23):3418. PMID: 41375476
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Houseknecht KL, et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun. 1998 Mar 27;244(3):678-82. [Content Brief]
[2]. Shultz TD, et al.Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett. 1992 Apr 15;63(2):125-33. [Content Brief]
[4]. Gervais, R., et al., (2009). Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows. Journal of dairy science, 92(10), 5167–5177. [Content Brief]
[5]. Park, Y., et al., (1999). Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 34(3), 235–241. [Content Brief]
[6]. Rajakangas, J., et al., (2003). Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappaB and cyclin D1 protein levels in the Min mouse. The Journal of nutrition, 133(6), 1943–1948. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(10E,12Z)-Octadeca-10,12-dienoic acid Related Classifications
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