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  4. Lauric acid

Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

For research use only. We do not sell to patients.

CAS No. : 143-07-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Lauric acid:

Lauric acid Related Antibodies

Top Publications Citing Use of Products

    Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794.

    U937 human leukemia cells were treated with Lauric acid (LA-m), RSL3 or their combination in the absence or presence of ferroptosis inhibitor Lip-1 for 24 h, and their viability was assayed using CCK8.

    Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794.

    RINm5F rat insulinoma cells were exposed to Lauric acid (LA-m) and RSL3 alone or their combination in the absence or presence of ferroptosis inhibitor Lip-1 for 24 h, and the changes of cell viability were measured through crystal violet staining.

    Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794.

    U937 human leukemia cells were treated with Lauric acid (LA-m), LA-l or their combination for 24 h, and cell viability was assessed by CCK8.

    Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794.

    RINm5F rat insulinoma cells were treated with Lauric acid (LA-m), LA-l or their combination for 24 h, and cell viability was determined by crystal violet staining.

    Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794.

    After the treatment, the levels of intracellular LPO were quantified using flow cytometry after staining with Liperfluo in U937 human leukemia cells. "+" means: combination of Lauric acid and LA-l.

    Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794.

    CD36 and ACSL4 protein levels in A549 lung cancer cells with treatment with Lauric acid for 12 h.

    View All Endogenous Metabolite Isoform Specific Products:

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO EC50
    3.49 μM
    Compound: 18
    Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
    Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
    		[PMID: 31721581]
    CHO EC50
    8.87 μM
    Compound: 18
    Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
    Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
    		[PMID: 31721581]
    In Vitro

    Lauric acid (0.06-125 μg/ml, 24-72 h) has much stronger antimicrobial activity in P. acnes, S.aureus, and S. epidermidis[1].
    Lauric acid (5-50 μM, 24 h) increases glucose uptake and decreases GLUT-1 expression and cellular H2O2 production in insulin-resistant macrophages[2].
    Lauric acid (5-50 μM, 24 h) enhances mitochondrial content and mitochondrial biogenesis in the insulin-resistant macrophages[2].
    Lauric acid (5-50 μM, 24 h) promotes the gene expressions (PPAR-γ, TFAM and PGC-1α) in THP-1 macrophages[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Lauric acid Related Antibodies
    In Vivo

    Lauric acid (0.1 μg/μL, i.h., once time) can effectively relieve P. acnes-induced inflammation without detrimental effects on skin cells in mice injected with P. acnes[1].
    Lauric acid (1-10 mg/kg, i.v., once time) reduces blood pressure and heart rate in WKY and SHR rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    200.32

    Formula

    C12H24O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCCCCCCCCCC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (499.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    0.1 M NaOH : 10 mg/mL (49.92 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.9920 mL 24.9601 mL 49.9201 mL
    5 mM 0.9984 mL 4.9920 mL 9.9840 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (10.38 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (10.38 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.93%

    SDS (476 KB)

    COA (239 KB) HNMR (222 KB) MS (68 KB) GC (280 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    0.1 M NaOH / DMSO 1 mM 4.9920 mL 24.9601 mL 49.9201 mL 124.8003 mL
    5 mM 0.9984 mL 4.9920 mL 9.9840 mL 24.9601 mL
    10 mM 0.4992 mL 2.4960 mL 4.9920 mL 12.4800 mL
    15 mM 0.3328 mL 1.6640 mL 3.3280 mL 8.3200 mL
    20 mM 0.2496 mL 1.2480 mL 2.4960 mL 6.2400 mL
    25 mM 0.1997 mL 0.9984 mL 1.9968 mL 4.9920 mL
    30 mM 0.1664 mL 0.8320 mL 1.6640 mL 4.1600 mL
    40 mM 0.1248 mL 0.6240 mL 1.2480 mL 3.1200 mL
    DMSO 50 mM 0.0998 mL 0.4992 mL 0.9984 mL 2.4960 mL
    60 mM 0.0832 mL 0.4160 mL 0.8320 mL 2.0800 mL
    80 mM 0.0624 mL 0.3120 mL 0.6240 mL 1.5600 mL
    100 mM 0.0499 mL 0.2496 mL 0.4992 mL 1.2480 mL
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    Lauric acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lauric acid143-07-7Environmental PollutantsBacterialEndogenous MetaboliteEnvironmental ContaminantsTHP-1macrophagesbactericidalP. acnesS.aureusS. epidermidisInhibitorinhibitorinhibit

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