Palmitoleic acid

Name: Palmitoleic acid
Brand: MedChemExpress
SKU: HY-W011873
Rating: 5.0 (7 reviews)

Cat. No.: HY-W011873 Purity: 99.89%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

For research use only. We do not sell to patients.

CAS No. : 373-49-9

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Palmitoleic acid:

7 Publications Citing Use of MCE Palmitoleic acid

•Eur J Lipid Sci Technol. 2023 Feb 25.

Bio/Physico-chemical Assay

Flow Cytometry

Cell Imaging/Staining

Cell Proliferation/Viability Assay

: Palmitoleic acid purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]; Palmitoleic acid (POA; 20 μM; 24 h). The changes in cellular GSH levels were assessed using the GSH content kit.

: Palmitoleic acid purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]; Palmitoleic acid (POA; 20 μM; 24 h). The alterations in cellular MDA levels were measured using the MDA content kit.

: Palmitoleic acid purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]; Palmitoleic acid (POA; 20 μM; 24 h). The cellular lipid ROS was detected using C11- BODIPY 581/591 and analyzed by flow cytometry.

: Palmitoleic acid purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]; Palmitoleic acid (POA; 20 μM; 24 h). Alterations to the mitochondrial membrane potential assessed using fluorescence microscopy.

: Palmitoleic acid purchased from MedChemExpress. Usage Cited in: FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]; Palmitoleic acid (POA; 20 μM; 24 h). HUVEC cells were treated with POA, and cell viability was assessed using the CCK8 assay.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Purity & Documentation
References
Customer Review

Description

Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Palmitoleic acid is a kind of fatty acid in human milk^[1]. Among SHRSP given various fatty acids, a diet containing 1% Palmitoleic acid significantly improves the survival rate, with concomitant reduction in the incidence of stroke in spite of their excess NaCl intake through 1% NaCl water for drinking^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

254.41

Formula

C₁₆H₃₀O₂

CAS No.

373-49-9

Appearance

Liquid (Density: 0.894 g/cm³)

Color

Colorless to light yellow

SMILES

CCCCCC/C=C\CCCCCCCC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (393.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9307 mL	19.6533 mL	39.3066 mL
5 mM	0.7861 mL	3.9307 mL	7.8613 mL
10 mM	0.3931 mL	1.9653 mL	3.9307 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (78.61 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (269 KB) SDS (394 KB)

COA (242 KB) HNMR (118 KB) RP-HPLC (237 KB) MS (73 KB)

Handling Instructions (2659 KB)

References

[1]. Ogunleye A, et al. Fatty acid composition of breast milk from Nigerian and Japanese women. J Nutr Sci Vitaminol (Tokyo). 1991 Aug;37(4):435-42. [Content Brief]

[2]. Yamori Y, et al. Dietary prevention of stroke and its mechanisms in stroke-prone spontaneously hypertensive rats--preventive effect of dietary fibre and palmitoleic acid. J Hypertens Suppl. 1986 Oct;4(3):S449-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9307 mL	19.6533 mL	39.3066 mL	98.2666 mL
	5 mM	0.7861 mL	3.9307 mL	7.8613 mL	19.6533 mL
	10 mM	0.3931 mL	1.9653 mL	3.9307 mL	9.8267 mL
	15 mM	0.2620 mL	1.3102 mL	2.6204 mL	6.5511 mL
	20 mM	0.1965 mL	0.9827 mL	1.9653 mL	4.9133 mL
	25 mM	0.1572 mL	0.7861 mL	1.5723 mL	3.9307 mL
	30 mM	0.1310 mL	0.6551 mL	1.3102 mL	3.2756 mL
	40 mM	0.0983 mL	0.4913 mL	0.9827 mL	2.4567 mL
	50 mM	0.0786 mL	0.3931 mL	0.7861 mL	1.9653 mL
	60 mM	0.0655 mL	0.3276 mL	0.6551 mL	1.6378 mL
	80 mM	0.0491 mL	0.2457 mL	0.4913 mL	1.2283 mL
	100 mM	0.0393 mL	0.1965 mL	0.3931 mL	0.9827 mL