1. PI3K/Akt/mTOR
    Metabolic Enzyme/Protease
  2. PI3K
    Endogenous Metabolite
  3. Erucic acid

Erucic acid 

Cat. No.: HY-N7109 Purity: >97.0%
Handling Instructions

Erucic acid, a monounsaturated fatty acid (MUFA), is isolated from the seed of Raphanus sativus L. Erucic acid can readily cross the blood-brain barrier (BBB), it has been reported to normalize the accumulation of very long-chain fatty acids in the brain. Erucic acid can improve cognitive impairment and be effective against dementia .

For research use only. We do not sell to patients.

Erucic acid Chemical Structure

Erucic acid Chemical Structure

CAS No. : 112-86-7

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10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Erucic acid, a monounsaturated fatty acid (MUFA), is isolated from the seed of Raphanus sativus L. Erucic acid can readily cross the blood-brain barrier (BBB), it has been reported to normalize the accumulation of very long-chain fatty acids in the brain. Erucic acid can improve cognitive impairment and be effective against dementia [1].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Erucic acid (oral administration; 3 mg/kg) enhances the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus compared with that in the vehicle-treated control group[1].

Animal Model: Normal naïve mice[1]
Dosage: 3 mg/kg
Administration: Oral administration; 3 mg/kg
Result: Enhanced the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus.
Molecular Weight

338.57

Formula

C₂₂H₄₂O₂

CAS No.

112-86-7

SMILES

CCCCCCCC/C=C\CCCCCCCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (295.36 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9536 mL 14.7680 mL 29.5360 mL
5 mM 0.5907 mL 2.9536 mL 5.9072 mL
10 mM 0.2954 mL 1.4768 mL 2.9536 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.38 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: >97.0%

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Keywords:

Erucic acidPI3KEndogenous MetabolitePhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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Product name:
Erucic acid
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HY-N7109
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