α-Tocotrienol
Based on 1 Customer Validation
α-Tocotrienol is an isoform of vitamin E and found in vegetables, fruits, seeds, nuts, grains, and oils. Vitamin E plays a role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 58864-81-6
- Formula: C29H44O2
- Molecular Weight:424.66
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
>20 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay
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[PMID: 20022507] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 1
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Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay
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[PMID: 20022507] |
α-Tocotrienol (30-45 µM, 24 h) inhibits the proliferation of bovine aortic endothelial cell (BAEC, IC50=38.0 µM), inhibits the tubular structure formation, and exhibits anti-angiogenic effect[1].
α-Tocotrienol (2.5-50 μM, 24h) scavenges free radicals, inhibits lipid peroxidation and reduces the adhesion of monocytes (THP-1) to HUVECs, thereby exerting anti-inflammatory and anti-atherosclerotic effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:bovine aortic endothelial cell
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Concentration:30-45 µM
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Incubation Time:24 h
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Result:Inhibited the proliferation.
Chemical Information
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CAS No. 58864-81-6
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Appearance Oil
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Molecular Weight 424.66
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Formula C29H44O2
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Color Colorless to light yellow
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SMILES
OC1=C(C)C(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (235.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Miyazawa T, et al., Anti-angiogenic potential of tocotrienol in vitro. Biochemistry (Mosc). 2004 Jan;69(1):67-9. [Content Brief]
[2]. Noguchi N, et al., Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. Free Radic Biol Med. 2003 Jun 15;34(12):1614-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3548 mL | 11.7741 mL | 23.5483 mL | 58.8706 mL |
| 5 mM | 0.4710 mL | 2.3548 mL | 4.7097 mL | 11.7741 mL | |
| 10 mM | 0.2355 mL | 1.1774 mL | 2.3548 mL | 5.8871 mL | |
| 15 mM | 0.1570 mL | 0.7849 mL | 1.5699 mL | 3.9247 mL | |
| 20 mM | 0.1177 mL | 0.5887 mL | 1.1774 mL | 2.9435 mL | |
| 25 mM | 0.0942 mL | 0.4710 mL | 0.9419 mL | 2.3548 mL | |
| 30 mM | 0.0785 mL | 0.3925 mL | 0.7849 mL | 1.9624 mL | |
| 40 mM | 0.0589 mL | 0.2944 mL | 0.5887 mL | 1.4718 mL | |
| 50 mM | 0.0471 mL | 0.2355 mL | 0.4710 mL | 1.1774 mL | |
| 60 mM | 0.0392 mL | 0.1962 mL | 0.3925 mL | 0.9812 mL | |
| 80 mM | 0.0294 mL | 0.1472 mL | 0.2944 mL | 0.7359 mL | |
| 100 mM | 0.0235 mL | 0.1177 mL | 0.2355 mL | 0.5887 mL |
α-Tocotrienol Related Classifications
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