2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. GLUT
  5. GLUT3 Isoform

GLUT3

GLUT3 (SLC2A3) is a facilitative glucose transporter that supports high-affinity glucose uptake, especially in neurons and glucose-limited cellular environments[1][2]. Mechanistically, GLUT3 connects membrane glucose transport to glycolytic metabolism, nucleotide synthesis, and immune-cell inflammatory programming through GLUT3-dependent glucose uptake[3][4]. In disease models, high GLUT3 expression supports colorectal cancer growth under low-glucose stress through the AMPK/CREB1/GLUT3 axis and correlates with poor colorectal cancer outcomes[3]. Compared with GLUT1, GLUT3 shows distinct transport affinity despite conserved substrate coordination, and colorectal cancer studies report stronger GLUT3 dependence than GLUT1 dependence under glucose-limiting conditions[3][5]. For experimental applications, GLUT3 inhibitors identified by in silico ligand screening and yeast validation provide tools to probe GLUT3-dependent glucose transport and GLUT3-dependent cancer metabolism[6].

GLUT3 Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-100017
    BAY-876
    		Inhibitor 99.67%
    BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis.
  • HY-145597
    KL-11743
    		Inhibitor 99.40%
    KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis.
  • HY-139605
    GLUT inhibitor-1
    		Inhibitor 99.03%
    GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases.
  • HY-138976
    NV-5440
    		Inhibitor
    NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake.
  • HY-167857
    (Rac)-Glutipyran
    		Inhibitor
    (Rac)-Glutipyran is a broad-spectrum GLUT inhibitor that targets both GLUT1 and GLUT3. (Rac)-Glutipyran inhibits glucose uptake and suppresses the growth of multiple cancer cells, significantly inhibiting PANC-1 cell growth (IC50=1.8 μM) and glucose uptake (IC50=0.13 μM).