GLUT3

GLUT3 (SLC2A3) is a facilitative glucose transporter that supports high-affinity glucose uptake, especially in neurons and glucose-limited cellular environments^[1][2]. Mechanistically, GLUT3 connects membrane glucose transport to glycolytic metabolism, nucleotide synthesis, and immune-cell inflammatory programming through GLUT3-dependent glucose uptake^[3][4]. In disease models, high GLUT3 expression supports colorectal cancer growth under low-glucose stress through the AMPK/CREB1/GLUT3 axis and correlates with poor colorectal cancer outcomes^[3]. Compared with GLUT1, GLUT3 shows distinct transport affinity despite conserved substrate coordination, and colorectal cancer studies report stronger GLUT3 dependence than GLUT1 dependence under glucose-limiting conditions^[3][5]. For experimental applications, GLUT3 inhibitors identified by in silico ligand screening and yeast validation provide tools to probe GLUT3-dependent glucose transport and GLUT3-dependent cancer metabolism^[6].