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Cat. No.: HY-138976

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NV-5440

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake.

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CAS No.: 2226614-88-4
Formule: C₃₁H₃₆N₆O₃S
Masse moléculaire:572.73

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NV-5440 Chemical Structure

CAS No.: 2226614-88-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

mTORC1

GLUT1

GLUT2

GLUT3

GLUT4

Voir tous les produits spécifiques à Isoform mTOR :

Voir tous les produits spécifiques à Isoform GLUT :

In Vitro

NV-5440 potently inhibits ³H-2DG uptake in MCF7 cells with an IC₅₀ of 36 nM, and targets GLUT-1 through GLUT-4 but not GLUT-5^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NV-5440 (30 mg/kg; i.p.) inhibits mTORC1 activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[2]
Dosage:

30 mg/kg
Administration:

i.p.
Result:

Confirmed inhibition of
mTORC1 activity.

Chemical Information

CAS No. 2226614-88-4
Masse moléculaire 572.73
Formule C₃₁H₃₆N₆O₃S
SMILES

N#CC=1C=CC=CC1N2CCN(CC3=CC(C(=O)N4CCN(C=5C=CC=CC5S(=O)(=O)N)CC4)=C(C=C3C)C)CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. David John O'neill, et al. PHENYL mTORC INHIBITORS AND USES THEREOF. WO2018089433A1. https://patents.google.com/patent/WO2018089433A1/en?oq=WO2018089433+A1

[2]. Reckzeh ES, et al. Small-Molecule Inhibition of Glucose Transporters GLUT-1-4. Chembiochem. 2020;21(1-2):45-52. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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NV-5440

Voir tous les produits spécifiques à Isoform mTOR

Voir tous les produits spécifiques à Isoform GLUT

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NV-5440 Related Classifications

HY-138976 Related Classifications