2. PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. mTOR GLUT
  4. NV-5440

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake.

For research use only. We do not sell to patients.

NV-5440

NV-5440 Chemical Structure

CAS No. : 2226614-88-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

NV-5440 Related Antibodies

Top Publications Citing Use of Products

View All mTOR Isoform Specific Products:

View All Isoforms
mTOR mTORC1 mTORC2

View All GLUT Isoform Specific Products:

View All Isoforms
GLUT1 GLUT2 GLUT3 GLUT4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake[1][2].

IC50 & Target[1]

mTORC1

 

GLUT1

 

GLUT2

 

GLUT3

 

GLUT4

 

In Vitro

NV-5440 potently inhibits 3H-2DG uptake in MCF7 cells with an IC50 of 36 nM, and targets GLUT-1 through GLUT-4 but not GLUT-5[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NV-5440 Related Antibodies
In Vivo

NV-5440 (30 mg/kg; i.p.) inhibits mTORC1 activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[2]
Dosage: 30 mg/kg
Administration: i.p.
Result: Confirmed inhibition of
mTORC1 activity.
Molecular Weight

572.73

Formula

C31H36N6O3S
CAS No.
SMILES

N#CC=1C=CC=CC1N2CCN(CC3=CC(C(=O)N4CCN(C=5C=CC=CC5S(=O)(=O)N)CC4)=C(C=C3C)C)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

NV-5440 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NV-54402226614-88-4NV5440NV 5440mTORGLUTMammalian target of RapamycinGlucose transporterMCF7 cellsmTORC1GLUT-3glucose transporter inhibitorGLUT-1GLUT-2GLUT-4mTORC1 inhibitorGLUT-5Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NV-5440
Cat. No.:
HY-138976
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.