GLUT inhibitor-1
Based on 1 publication(s) in Google Scholar
GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.03%
- CAS. Nr.: 2421141-40-2
- Formel: C32H35N7O2
- Molecular Weight:549.67
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) GLUT inhibitor-1
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Biologische Aktivität
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GLUT1 242 nM (IC50) |
GLUT3 179 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
179 nM
Compound: 15b
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Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
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[PMID: 32282207] |
| DLD-1 | IC50 |
242 nM
Compound: 15b
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Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
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[PMID: 32282207] |
| Parameter | Mouse | Rat |
| oral Cmax (ng/mL) | 2525 | 1675 |
| oral AUC (ng/mL) | 5890 | 6813 |
| CL (mL/min/kg) | 40 | 37 |
| Vdss (L/Kg) | 1.70 | 4.51 |
| t1/2 (h) | 0.785 | 2.59 |
| F (%) | 45.4 | 49.4 |
| B/Pb | 0.05 |
b: Solubility is determined in PBS buffer solutions.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2421141-40-2
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Appearance Solid
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Molecular Weight 549.67
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Formel C32H35N7O2
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Color Light yellow to yellow
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SMILES
O=C(COC1=CC=CC(C2=NC(CCN(C3CCC3)C4)=C4C(NC5=CC=C(C6=CNN=C6)C=C5)=N2)=C1)NC7(CC7)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (181.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8193 mL | 9.0964 mL | 18.1927 mL | 45.4818 mL |
| 5 mM | 0.3639 mL | 1.8193 mL | 3.6385 mL | 9.0964 mL | |
| 10 mM | 0.1819 mL | 0.9096 mL | 1.8193 mL | 4.5482 mL | |
| 15 mM | 0.1213 mL | 0.6064 mL | 1.2128 mL | 3.0321 mL | |
| 20 mM | 0.0910 mL | 0.4548 mL | 0.9096 mL | 2.2741 mL | |
| 25 mM | 0.0728 mL | 0.3639 mL | 0.7277 mL | 1.8193 mL | |
| 30 mM | 0.0606 mL | 0.3032 mL | 0.6064 mL | 1.5161 mL | |
| 40 mM | 0.0455 mL | 0.2274 mL | 0.4548 mL | 1.1370 mL | |
| 50 mM | 0.0364 mL | 0.1819 mL | 0.3639 mL | 0.9096 mL | |
| 60 mM | 0.0303 mL | 0.1516 mL | 0.3032 mL | 0.7580 mL | |
| 80 mM | 0.0227 mL | 0.1137 mL | 0.2274 mL | 0.5685 mL | |
| 100 mM | 0.0182 mL | 0.0910 mL | 0.1819 mL | 0.4548 mL |
GLUT inhibitor-1 Related Classifications
HY-139605 Related Classifications
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