1. Membrane Transporter/Ion Channel
  2. GLUT
  3. GLUT inhibitor-1

GLUT inhibitor-1 

Cat. No.: HY-139605
Handling Instructions

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases.

For research use only. We do not sell to patients.

GLUT inhibitor-1 Chemical Structure

GLUT inhibitor-1 Chemical Structure

CAS No. : 2421141-40-2

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Description

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].

IC50 & Target

GLUT1

242 nM (IC50)

GLUT3

179 nM (IC50)

In Vivo

Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1].

Parameter Mouse Rat
oral Cmax (ng/mL) 2525 1675
oral AUC (ng/mL) 5890 6813
CL (mL/min/kg) 40 37
Vdss (L/Kg) 1.70 4.51
t1/2 (h) 0.785 2.59
F (%) 45.4 49.4
B/Pb 0.05

b: Solubility is determined in PBS buffer solutions.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

549.67

Formula

C₃₂H₃₅N₇O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
GLUT inhibitor-1
Cat. No.:
HY-139605
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