2. Membrane Transporter/Ion Channel
  3. GLUT
  4. GLUT inhibitor-1

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases.

For research use only. We do not sell to patients.

GLUT inhibitor-1 Chemical Structure

GLUT inhibitor-1 Chemical Structure

CAS No. : 2421141-40-2

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Based on 1 publication(s) in Google Scholar

GLUT inhibitor-1 Related Antibodies

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1 Publications Citing Use of MCE GLUT inhibitor-1

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  • Biological Activity

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Description

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].

IC50 & Target

GLUT1

242 nM (IC50)

GLUT3

179 nM (IC50)

In Vivo

Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1].

Parameter Mouse Rat
oral Cmax (ng/mL) 2525 1675
oral AUC (ng/mL) 5890 6813
CL (mL/min/kg) 40 37
Vdss (L/Kg) 1.70 4.51
t1/2 (h) 0.785 2.59
F (%) 45.4 49.4
B/Pb 0.05

b: Solubility is determined in PBS buffer solutions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

549.67

Formula

C32H35N7O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(COC1=CC=CC(C2=NC(CCN(C3CCC3)C4)=C4C(NC5=CC=C(C6=CNN=C6)C=C5)=N2)=C1)NC7(CC7)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (181.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8193 mL 9.0964 mL 18.1927 mL
5 mM 0.3639 mL 1.8193 mL 3.6385 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8193 mL 9.0964 mL 18.1927 mL 45.4818 mL
5 mM 0.3639 mL 1.8193 mL 3.6385 mL 9.0964 mL
10 mM 0.1819 mL 0.9096 mL 1.8193 mL 4.5482 mL
15 mM 0.1213 mL 0.6064 mL 1.2128 mL 3.0321 mL
20 mM 0.0910 mL 0.4548 mL 0.9096 mL 2.2741 mL
25 mM 0.0728 mL 0.3639 mL 0.7277 mL 1.8193 mL
30 mM 0.0606 mL 0.3032 mL 0.6064 mL 1.5161 mL
40 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1370 mL
50 mM 0.0364 mL 0.1819 mL 0.3639 mL 0.9096 mL
60 mM 0.0303 mL 0.1516 mL 0.3032 mL 0.7580 mL
80 mM 0.0227 mL 0.1137 mL 0.2274 mL 0.5685 mL
100 mM 0.0182 mL 0.0910 mL 0.1819 mL 0.4548 mL
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GLUT inhibitor-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLUT inhibitor-12421141-40-2GLUT inhibitor1GLUT inhibitor 1GLUTGlucose transporterGLUT1GLUT3oralaerobic glycolysisanti-cancerautoimmuneWarburgglucose transporterInhibitorinhibitorinhibit

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