2. Membrane Transporter/Ion Channel
  3. GLUT
  4. BAY-876

BAY-876 

Cat. No.: HY-100017 Purity: 98.04%
COA Handling Instructions

BAY-876 est un inhibiteur puissant, sélectif du transporteur de glucose 1 (GLUT1) et oralement actif avec un IC50 de 2 nM. BAY-876 est> 130 fois plus sélectif pour GLUT1 que GLUT2, GLUT3 et GLUT4. BAY-876 est également un inhibiteur puissant du métabolisme glycolytique et de la croissance du cancer de l'ovaire.

BAY-876 ist ein potenter, selektiver und oral wirksamer glucose transporter 1 (GLUT1)-Inhibitor mit einem IC50 von 2 nM. BAY-876 ist >130-mal selektiver für GLUT1 als GLUT2, GLUT3 und GLUT4. BAY-876 ist auch ein potenter Blocker des glykolytischen Stoffwechsels und des Ovarialkarzinom-Wachstums.

BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth.

For research use only. We do not sell to patients.

BAY-876 Chemical Structure

BAY-876 Chemical Structure

CAS No. : 1799753-84-6

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solid
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5 mg USD 120 In-stock
10 mg USD 180 In-stock
50 mg USD 540 In-stock
100 mg USD 900 In-stock
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Based on 13 publication(s) in Google Scholar

BAY-876 Related Antibodies

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GLUT1 GLUT2 GLUT3 GLUT4

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Description

BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth[2].

IC50 & Target[1]

GLUT1

2 nM (IC50)

GLUT2

10.08 μM (IC50)

GLUT3

1.67 μM (IC50)

GLUT4

0.29 μM (IC50)

In Vitro

BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-876 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: SKOV-3 and OVCAR-3 cells
Concentration: 25, 50, 75 nM
Incubation Time: 24 and 72 hours
Result: Led to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells.
In Vivo

BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts[2]
Dosage: 1.5, 3, 4.5 mg/kg
Administration: Oral administration; daily; for 28 days
Result: Caused a clear dose-dependent inhibition of tumorigenicity.
Molecular Weight

496.42

Appearance

Solid

Formula

C24H16F4N6O2
CAS No.
SMILES

O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (201.44 mM)

Methanol : 1 mg/mL (2.01 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0144 mL 10.0721 mL 20.1442 mL
5 mM 0.4029 mL 2.0144 mL 4.0288 mL
10 mM 0.2014 mL 1.0072 mL 2.0144 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 5 mg/mL (10.07 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.46%

COA (259 KB) HNMR (180 KB) LCMS (349 KB)

Handling Instructions (2659 KB)
References
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BAY-876 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

BAY-8761799753-84-6BAY876BAY 876GLUTGlucose transporterorallyglucosetransporter1glycolyticmetabolismovariancancerInhibitorinhibitorinhibit

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