Fmoc-PNA-C(Bhoc)-OH
Based on 1 Customer Validation
Fmoc-PNA-C (Bhoc)-OH is a cytosine peptide nucleic acid (PNA) monomer protected by Fmoc/Bhoc. Fmoc-PNA-C (Bhoc)-OH can be used for solid-phase synthesis of long-chain PNAs, including the 20-mer PNA targeting Nnmt mRNA and the PNA targeting the tyrosinease gene to inhibit melanogenesis. Fmoc-PNA-C (Bhoc)-OH can be applied in studies related to type 2 diabetes and Escherichia coli infections.
For research use only. We do not sell to patients.
- Purity: 96.25%
- CAS No.: 186046-81-1
- Formula: C39H35N5O8
- Molecular Weight:701.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W540123
Fmoc-PNA-A(Bhoc)-OH
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HY-W009124
Fmoc-D-Pro-OH
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HY-W013780
Fmoc-Pro-OH
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HY-W010712
Fmoc-His(Trt)-OH
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HY-W402665
Fmoc-PNA-T-OH
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HY-W008072
Fmoc-D-Ala-OH
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HY-W025936
Fmoc-PNA-G(Bhoc)-OH
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HY-W007942
Fmoc-β-Ala-OH
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HY-W011000
Fmoc-Cha-OH
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HY-79130
Fmoc-(S)-phenylglycine
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HY-W013760
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetic acid
Biological Activity
Using NMP (N-Methylpyrrolidone) (HY-Y1275) as the solvent (with Oxyma as the condensing agent and additional resin washing steps), Fmoc-PNA-C (Bhoc)-OH enables efficient solid-phase synthesis of pure long-chain PNA oligomers (up to 20-mer) and their conjugates[1].
Fmoc-PNA-C (Bhoc)-OH can be efficiently incorporated into PNA/peptide conjugates via manual solid-phase synthesis performed on Wang resin[2].
Fmoc-PNA-C (Bhoc)-OH is a monomer used for the solid-phase synthesis of PNA oligomers, which can be incorporated into the (KFF)3K-AEEA-PNA antimicrobial conjugate[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 186046-81-1
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Appearance Solid
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Molecular Weight 701.72
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Formula C39H35N5O8
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Color White to off-white
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SMILES
O=C(NC1=NC(N(CC(N(CC(O)=O)CCNC(OCC2C3=CC=CC=C3C4=CC=CC=C24)=O)=O)C=C1)=O)OC(C5=CC=CC=C5)C6=CC=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 35 mg/mL (49.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Lygina AS, et al. Transmembrane domain peptide/peptide nucleic acid hybrid as a model of a SNARE protein in vesicle fusion. Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8597-601. [Content Brief]
[3]. Równicki M, et al. Artificial Activation of Escherichia coli mazEF and hipBA Toxin-Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy. Front Microbiol. 2018 Nov 26;9:2870. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4251 mL | 7.1253 mL | 14.2507 mL | 35.6267 mL |
| 5 mM | 0.2850 mL | 1.4251 mL | 2.8501 mL | 7.1253 mL | |
| 10 mM | 0.1425 mL | 0.7125 mL | 1.4251 mL | 3.5627 mL | |
| 15 mM | 0.0950 mL | 0.4750 mL | 0.9500 mL | 2.3751 mL | |
| 20 mM | 0.0713 mL | 0.3563 mL | 0.7125 mL | 1.7813 mL | |
| 25 mM | 0.0570 mL | 0.2850 mL | 0.5700 mL | 1.4251 mL | |
| 30 mM | 0.0475 mL | 0.2375 mL | 0.4750 mL | 1.1876 mL | |
| 40 mM | 0.0356 mL | 0.1781 mL | 0.3563 mL | 0.8907 mL |
Fmoc-PNA-C(Bhoc)-OH Related Classifications
HY-W540122 Related Classifications
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