186046-81-1
Chemical Structure
Fmoc-PNA-C(Bhoc)-OH
- CAS No.: 186046-81-1
- Formula:C39H35N5O8
- Molecular Weight:701.72
IUPAC Name: N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-N-(2-(6-(((benzhydryloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)glycine
InChIKey: YPTOIRLDQISSCH-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(N(CC(N(CC(O)=O)CCNC(OCC2C3=CC=CC=C3C4=CC=CC=C24)=O)=O)C=C1)=O)OC(C5=CC=CC=C5)C6=CC=CC=C6
Biological Activity: Fmoc-PNA-C (Bhoc)-OH is a cytosine peptide nucleic acid (PNA) monomer protected by Fmoc/Bhoc. Fmoc-PNA-C (Bhoc)-OH can be used for solid-phase synthesis of long-chain PNAs, including the 20-mer PNA targeting Nnmt mRNA and the PNA targeting the tyrosinease gene to inhibit melanogenesis. Fmoc-PNA-C (Bhoc)-OH can be applied in studies related to type 2 diabetes and Escherichia coli infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fmoc-PNA-C(Bhoc)-OH | 96.25% | Fmoc-PNA-C (Bhoc)-OH is a cytosine peptide nucleic acid (PNA) monomer protected by Fmoc/Bhoc. Fmoc-PNA-C (Bhoc)-OH can be used for solid-phase synthesis of long-chain PNAs, including the 20-mer PNA targeting Nnmt mRNA and the PNA targeting the tyrosinease gene to inhibit melanogenesis. Fmoc-PNA-C (Bhoc)-OH can be applied in studies related to type 2 diabetes and Escherichia coli infections. | ||||||||||||||||||||
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- [1]. Yagita R, et al. Synthesis and physicochemical properties of 20‑mer peptide nucleic acid conjugates with testosterone 17β‑carboxylic acid. Tetrahedron Letters. 2020 Apr 23;61(17):151781.
- [2]. Lygina AS, et al. Transmembrane domain peptide/peptide nucleic acid hybrid as a model of a SNARE protein in vesicle fusion. Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8597-601. [Content Brief]
- [3]. Równicki M, et al. Artificial Activation of Escherichia coli mazEF and hipBA Toxin-Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy. Front Microbiol. 2018 Nov 26;9:2870. [Content Brief]
Keywords
