N-Methylpyrrolidone
Based on 1 Customer Validation
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 872-50-4
- Formula: C5H9NO
- Molecular Weight:99.13
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Storage:
Store at room temperature 3 years
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
N-Methylpyrrolidone (5.0 mM, 11 h) is removed by NJUST38 with the supplementation of nitrate into anoxic system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[3]
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Dosage:0-30000 ppm
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Administration:feed, daily for 28 days
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Result:Showed hematological (mild to moderate leukopenia) and histopathological alterations (hypocellular bone marrow, testicular degeneration and atrophy, and thymic atrophy), and cloudy swelling of the epithelia of the distal parts of the renal tubuli in mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 872-50-4
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Appearance Liquid (Density: 1.03 g/mL)
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Molecular Weight 99.13
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Formula C5H9NO
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Color Colorless to light yellow
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SMILES
O=C1N(C)CCC1
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Synonyms
NMP; 1-Methyl-2-pyrrolidinone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
Solvent & Solubility
DMSO : 100 mg/mL (1008.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (560 KB)
- English - EN (560 KB)
- Français - FR (560 KB)
- Deutsch - DE (560 KB)
- Norwegian - NO (560 KB)
- Español - ES (560 KB)
- Swedish - SV (560 KB)
- Italian - IT (560 KB)
- Korean - KR (560 KB)
- Portuguese - PT (560 KB)
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Handling Instructions (2659 KB)
References
[1]. Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185. [Content Brief]
[2]. Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 15;84(1):e02136-17. [Content Brief]
[3]. Malek DE, et al. Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP). Drug Chem Toxicol. 1997 Feb-May;20(1-2):63-77. [Content Brief]
[4]. Malley LA, et al. 90-day subchronic toxicity study in rats and mice fed N-methylpyrrolidone (NMP) including neurotoxicity evaluation in rats. Drug Chem Toxicol. 1999 Aug;22(3):455-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 10.0878 mL | 50.4388 mL | 100.8776 mL | 252.1941 mL |
| 5 mM | 2.0176 mL | 10.0878 mL | 20.1755 mL | 50.4388 mL | |
| 10 mM | 1.0088 mL | 5.0439 mL | 10.0878 mL | 25.2194 mL | |
| 15 mM | 0.6725 mL | 3.3626 mL | 6.7252 mL | 16.8129 mL | |
| 20 mM | 0.5044 mL | 2.5219 mL | 5.0439 mL | 12.6097 mL | |
| 25 mM | 0.4035 mL | 2.0176 mL | 4.0351 mL | 10.0878 mL | |
| 30 mM | 0.3363 mL | 1.6813 mL | 3.3626 mL | 8.4065 mL | |
| 40 mM | 0.2522 mL | 1.2610 mL | 2.5219 mL | 6.3049 mL | |
| 50 mM | 0.2018 mL | 1.0088 mL | 2.0176 mL | 5.0439 mL | |
| 60 mM | 0.1681 mL | 0.8406 mL | 1.6813 mL | 4.2032 mL | |
| 80 mM | 0.1261 mL | 0.6305 mL | 1.2610 mL | 3.1524 mL | |
| 100 mM | 0.1009 mL | 0.5044 mL | 1.0088 mL | 2.5219 mL |
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