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  3. Asimilobine

Asimilobine 

Cat. No.: HY-N7512
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Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

For research use only. We do not sell to patients.

Asimilobine Chemical Structure

Asimilobine Chemical Structure

CAS No. : 6871-21-2

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Description

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].

IC50 & Target[1][2]

Dopamine Receptor

 

serotonergic receptor

 

In Vitro

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM[2].
Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h[2].
Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels[2].

Molecular Weight

267.32

Formula

C₁₇H₁₇NO₂

CAS No.

6871-21-2

SMILES

OC1=C(OC)C2=C3C(CCN[[email protected]]3([H])CC4=CC=CC=C24)=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AsimilobineDopamine Receptor5-HT ReceptorParasiteSerotonin Receptor5-hydroxytryptamine ReceptoraporphineisoquinolinealkaloidtyrosinehydroxylaseTHaromaticL-aminoaciddecarboxylaseAADCmRNAInhibitorinhibitorinhibit

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