2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. Dopamine Receptor 5-HT Receptor Parasite
  4. Asimilobine

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

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Asimilobine Chemical Structure

Asimilobine Chemical Structure

CAS No. : 6871-21-2

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Based on 1 publication(s) in Google Scholar

Asimilobine Related Antibodies

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Description

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].

IC50 & Target[1][2]

Plasmodium

 

Dopamine Receptor

 

serotonergic receptor

 

In Vitro

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM[2].
Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h[2].
Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Asimilobine Related Antibodies
Molecular Weight

267.32

Formula

C17H17NO2
CAS No.
SMILES

OC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Asimilobine Related Classifications

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Keywords:

Asimilobine6871-21-2Dopamine Receptor5-HT ReceptorParasiteSerotonin Receptor5-hydroxytryptamine ReceptoraporphineisoquinolinealkaloidtyrosinehydroxylaseTHaromaticL-aminoaciddecarboxylaseAADCmRNAInhibitorinhibitorinhibit

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