6871-21-2
6871-21-2
Chemical Structure
Asimilobine
- CAS No.: 6871-21-2
- Formula:C17H17NO2
- Molecular Weight:267.32
IUPAC Name: (R)-1-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
InChIKey: NBDNEUOVIJYCGZ-CYBMUJFWSA-N
SMILES: OC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1
Biological Activity: Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].
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Asimilobine | 99.90% | Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-N2129N-Nornuciferine -
Similarity Score 0.84
HY-N2129AN-Nornuciferine hydrochloride -
Similarity Score 0.80
HY-N7511O-Nornuciferine -
Similarity Score 0.80
HY-N79712-Hydroxy-1-Methoxyaporphine -
Similarity Score 0.76
HY-1790085-HT2CR agonist 2 -
Similarity Score 0.76
HY-179008A(S)-5-HT2CR agonist 1 -
Similarity Score 0.75
HY-N4307Laetanine -
Similarity Score 0.75
HY-N2352Laurolitsine -
Similarity Score 0.74
HY-N7227Anonaine -
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References
- [1]. N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50(4):773-4. [Content Brief]
- [2]. Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10(7-8):747-55. [Content Brief]
