Anonaine
Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1862-41-5
- Formula: C17H15NO2
- Molecular Weight:265.31
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
All Parasite Isoforms
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Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | ED50 |
4.2 μg/mL
Compound: 3
|
Cytotoxicity against human A431 cells after 3 days by SRB assay
Cytotoxicity against human A431 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| AGS | IC50 |
8.6 μM
Compound: 5
|
Cytotoxicity against human AGS cells by MTS colorimetric assay
Cytotoxicity against human AGS cells by MTS colorimetric assay
|
[PMID: 11087586] |
| DLD-1 | IC50 |
28.9 μM
Compound: 5
|
Cytotoxicity against human DLD1 cells by MTS colorimetric assay
Cytotoxicity against human DLD1 cells by MTS colorimetric assay
|
[PMID: 11087586] |
| HeLa | IC50 |
24.8 μg/mL
Compound: Anonaine, III
|
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
|
[PMID: 18295494] |
| Hepatocyte | IC50 |
70.3 μg/mL
Compound: Anonaine, III
|
Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay
Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay
|
[PMID: 18295494] |
| HepG2 | IC50 |
20.8 μM
Compound: 5
|
Cytotoxicity against human HepG2 cells by MTS colorimetric assay
Cytotoxicity against human HepG2 cells by MTS colorimetric assay
|
[PMID: 11087586] |
| HepG2 | IC50 |
33.5 μg/mL
Compound: Anonaine, III
|
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
|
[PMID: 18295494] |
| HT-1080 | ED50 |
2.4 μg/mL
Compound: 3
|
Cytotoxicity against human HT1080 cells after 3 days by SRB assay
Cytotoxicity against human HT1080 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| KB | ED50 |
2.6 μg/mL
Compound: 3
|
Cytotoxicity against human KB cells after 3 days by SRB assay
Cytotoxicity against human KB cells after 3 days by SRB assay
|
[PMID: 8254346] |
| KB-V1 | ED50 |
1.8 μg/mL
Compound: 3
|
Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay
Cytotoxicity against vinblastine-resistant human KBV1 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| LNCaP | ED50 |
2.9 μg/mL
Compound: 3
|
Cytotoxicity against human LNCAP cells after 3 days by SRB assay
Cytotoxicity against human LNCAP cells after 3 days by SRB assay
|
[PMID: 8254346] |
| P388 | ED50 |
>5 μg/mL
Compound: 3
|
Cytotoxicity against mouse P388 cells after 3 days by SRB assay
Cytotoxicity against mouse P388 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| SK-MEL-2 | ED50 |
15.8 μg/mL
Compound: 3
|
Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| U-373MG ATCC | ED50 |
1.5 μg/mL
Compound: 3
|
Cytotoxicity against human U373 cells after 3 days by SRB assay
Cytotoxicity against human U373 cells after 3 days by SRB assay
|
[PMID: 8254346] |
| ZR-75-1 | ED50 |
2.7 μg/mL
Compound: 3
|
Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
|
[PMID: 8254346] |
Chemical Information
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CAS No. 1862-41-5
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Appearance Solid
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Molecular Weight 265.31
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Formula C17H15NO2
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Color Light brown to brown
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SMILES
[H][C@@]1(NCC2)CC3=CC=CC=C3C4=C1C2=CC5=C4OCO5
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)