1. Autophagy
    Apoptosis
    Metabolic Enzyme/Protease
  2. Autophagy
    Apoptosis
    Endogenous Metabolite
  3. Lithocholic acid

Lithocholic acid (Synonyms: 3α-Hydroxy-5β-cholanic acid)

Cat. No.: HY-B0172 Purity: >98.0%
Handling Instructions

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity.

For research use only. We do not sell to patients.

Lithocholic acid Chemical Structure

Lithocholic acid Chemical Structure

CAS No. : 434-13-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 96 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products
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  • Purity & Documentation

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Description

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity. Target: Others Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

376.57

Formula

C₂₄H₄₀O₃

CAS No.

434-13-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (398.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6555 mL 13.2777 mL 26.5555 mL
5 mM 0.5311 mL 2.6555 mL 5.3111 mL
10 mM 0.2656 mL 1.3278 mL 2.6555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

Lithocholic acid3α-Hydroxy-5β-cholanic acidAutophagyApoptosisEndogenous MetaboliteInhibitorinhibitorinhibit

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Lithocholic acid
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HY-B0172
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