1. Autophagy
    Metabolic Enzyme/Protease
    Apoptosis
  2. Autophagy
    Endogenous Metabolite
    Apoptosis
  3. Lithocholic acid

Lithocholic acid (Synonyms: 3α-Hydroxy-5β-cholanic acid)

Cat. No.: HY-B0172 Purity: ≥98.0%
Handling Instructions

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity.

For research use only. We do not sell to patients.

Lithocholic acid Chemical Structure

Lithocholic acid Chemical Structure

CAS No. : 434-13-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 106 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Lithocholic acid:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity. Target: Others Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

Molecular Weight

376.57

Formula

C24H40O3

CAS No.
SMILES
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (663.89 mM; Need ultrasonic)

Ethanol : 10 mg/mL (26.56 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6555 mL 13.2777 mL 26.5555 mL
5 mM 0.5311 mL 2.6555 mL 5.3111 mL
10 mM 0.2656 mL 1.3278 mL 2.6555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.66 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.66 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 1 mg/mL (2.66 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Lithocholic acid
Cat. No.:
HY-B0172
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