Lithocholic acid-d5
Based on 1 Customer Validation
Lithocholic acid-d5 is deuterium labeled Lithocholic acid.
For research use only. We do not sell to patients.
- CAS No.: 52840-06-9
- Formula: C24H35D5O3
- Molecular Weight:381.60
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 52840-06-9
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Unlabeled Cas 434-13-9
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Appearance Solid
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Molecular Weight 381.60
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Formula C24H35D5O3
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C([2H])([2H])[C@](C([2H])([2H])C4)([2H])O)([H])CC3)C
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Synonyms
3α-Hydroxy-5β-cholanic acid-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (262.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21-6. [Content Brief]
[3]. Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260. [Content Brief]
[4]. Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2(10): p. 761-82. [Content Brief]
[5]. Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6205 mL | 13.1027 mL | 26.2055 mL | 65.5136 mL |
| 5 mM | 0.5241 mL | 2.6205 mL | 5.2411 mL | 13.1027 mL | |
| 10 mM | 0.2621 mL | 1.3103 mL | 2.6205 mL | 6.5514 mL | |
| 15 mM | 0.1747 mL | 0.8735 mL | 1.7470 mL | 4.3676 mL | |
| 20 mM | 0.1310 mL | 0.6551 mL | 1.3103 mL | 3.2757 mL | |
| 25 mM | 0.1048 mL | 0.5241 mL | 1.0482 mL | 2.6205 mL | |
| 30 mM | 0.0874 mL | 0.4368 mL | 0.8735 mL | 2.1838 mL | |
| 40 mM | 0.0655 mL | 0.3276 mL | 0.6551 mL | 1.6378 mL | |
| 50 mM | 0.0524 mL | 0.2621 mL | 0.5241 mL | 1.3103 mL | |
| 60 mM | 0.0437 mL | 0.2184 mL | 0.4368 mL | 1.0919 mL | |
| 80 mM | 0.0328 mL | 0.1638 mL | 0.3276 mL | 0.8189 mL | |
| 100 mM | 0.0262 mL | 0.1310 mL | 0.2621 mL | 0.6551 mL |
Lithocholic acid-d5 Related Classifications
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