Lithocholic acid-d₅ (Synonyms: 3α-Hydroxy-5β-cholanic acid-d₅)

Name: Lithocholic acid-d 5
Brand: MedChemExpress
SKU: HY-B0172S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0172S1 Purity: 99.99%: Data Sheet
COA

SDS
Handling Instructions
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Lithocholic acid-d₅ is deuterium labeled Lithocholic acid.

For research use only. We do not sell to patients.

Lithocholic acid-d₅ Chemical Structure

CAS No. : 52840-06-9

Size	Stock	Quantity
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Lithocholic acid-d₅:

Lithocholic acid In-stock

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Description

Lithocholic acid-d₅ is deuterium labeled Lithocholic acid.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

381.60

Formula

C₂₄H₃₅D₅O₃

CAS No.

52840-06-9

Unlabeled CAS

434-13-9

Appearance

Solid

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C([2H])([2H])[C@](C([2H])([2H])C4)([2H])O)([H])CC3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (262.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6205 mL	13.1027 mL	26.2055 mL
5 mM	0.5241 mL	2.6205 mL	5.2411 mL
10 mM	0.2621 mL	1.3103 mL	2.6205 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (273 KB) SDS (254 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21-6. [Content Brief]

[3]. Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260. [Content Brief]

[4]. Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2(10): p. 761-82. [Content Brief]

[5]. Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6205 mL	13.1027 mL	26.2055 mL	65.5136 mL
	5 mM	0.5241 mL	2.6205 mL	5.2411 mL	13.1027 mL
	10 mM	0.2621 mL	1.3103 mL	2.6205 mL	6.5514 mL
	15 mM	0.1747 mL	0.8735 mL	1.7470 mL	4.3676 mL
	20 mM	0.1310 mL	0.6551 mL	1.3103 mL	3.2757 mL
	25 mM	0.1048 mL	0.5241 mL	1.0482 mL	2.6205 mL
	30 mM	0.0874 mL	0.4368 mL	0.8735 mL	2.1838 mL
	40 mM	0.0655 mL	0.3276 mL	0.6551 mL	1.6378 mL
	50 mM	0.0524 mL	0.2621 mL	0.5241 mL	1.3103 mL
	60 mM	0.0437 mL	0.2184 mL	0.4368 mL	1.0919 mL
	80 mM	0.0328 mL	0.1638 mL	0.3276 mL	0.8189 mL
	100 mM	0.0262 mL	0.1310 mL	0.2621 mL	0.6551 mL

Lithocholic acid-d₅ Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lithocholic acid-d₅52840-06-93α-Hydroxy-5β-cholanic acid-d₅Isotope-Labeled CompoundsAutophagyEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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Lithocholic acid-d5 (Synonyms: 3α-Hydroxy-5β-cholanic acid-d5)

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Complete Stock Solution Preparation Table

Lithocholic acid-d5 Related Classifications

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Lithocholic acid-d₅ (Synonyms: 3α-Hydroxy-5β-cholanic acid-d₅)

Other Forms of Lithocholic acid-d₅:

Lithocholic acid-d₅ Related Antibodies

Lithocholic acid-d₅ Related Antibodies

Lithocholic acid-d₅ Related Classifications