1. Immunology/Inflammation
  2. CD73
  3. CD73-IN-4

CD73-IN-4 

Cat. No.: HY-131967
Handling Instructions

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology.

For research use only. We do not sell to patients.

CD73-IN-4 Chemical Structure

CD73-IN-4 Chemical Structure

CAS No. : 2216764-29-1

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Description

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology[1].

IC50 & Target

CD73[1]

In Vitro

CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10 000 nM) against CD39, A2aR, and NTPDase2, 3, and 8[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

463.81

Formula

C₁₆H₂₃ClN₅O₇P

CAS No.

2216764-29-1

SMILES

O[[email protected]@H]1[[email protected]](O[[email protected]]([[email protected]@H]1O)N2C3=C(C=N2)C(NC4CCCC4)=NC(Cl)=N3)COCP(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CD73-IN-4CD73ecto-5′-nucleotidase, NT5Emethylenephosphonicacidclusterofdifferentiation735'-Ribonucleotide phosphohydrolasecancerimmunologyInhibitorinhibitorinhibit

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CD73-IN-4
Cat. No.:
HY-131967
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