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  4. Boc-L-Ala-OH

Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Boc-L-Ala-OH

Boc-L-Ala-OH Chemical Structure

CAS No. : 15761-38-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Boc-L-Ala-OH:

Boc-L-Ala-OH Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Boc-L-Ala-OH

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
A-375 GI50
> 100 nM
Compound: 16
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as cell growth inhibition preincubated with compound for 1 hrs followed by 365 nm light irradiation for 5 mins and measured 72 hrs post compound treatment by CellTiter-Glo luminescent assay
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as cell growth inhibition preincubated with compound for 1 hrs followed by 365 nm light irradiation for 5 mins and measured 72 hrs post compound treatment by CellTiter-Glo luminescent assay
[PMID: 36924668]
A-375 GI50
> 100 μM
Compound: 16
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as cell growth inhibition incubated for 72 hrs in the absence of UV irradiation by CellTiter-Glo luminescent assay
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as cell growth inhibition incubated for 72 hrs in the absence of UV irradiation by CellTiter-Glo luminescent assay
[PMID: 36924668]
HEK-293T GI50
> 100 μM
Compound: 16
Cytotoxicity against HEK293T cells assessed as cell growth inhibition preincubated with compound for 1 hrs followed by 365 nm light irradiation for 5 mins and measured 72 hrs post compound treatment by CellTiter-Glo luminescent assay
Cytotoxicity against HEK293T cells assessed as cell growth inhibition preincubated with compound for 1 hrs followed by 365 nm light irradiation for 5 mins and measured 72 hrs post compound treatment by CellTiter-Glo luminescent assay
[PMID: 36924668]
In Vitro

Boc-L-Ala-OH (0.20-0.80 mmol; 0 °C) is used to synthesize two protected peptide intermediates, Boc-Ala-Arg (NO2)-Pro-OBzl and Boc-Ala-Arg (NO2)-Pro-Ala-OBzl, via solution-phase stepwise coupling and deprotection reactions, with yields of 87% and 80%, respectively[4].
Boc-L-Ala-OH (0.20 mmol; RT; 24 h) can be incorporated into Boc-Ala-Arg (NO2)-Pro-OBzl and Boc-Ala-Arg (NO2)-Pro-Ala-OBzl, and after deprotection, H-Ala-Arg-Pro-OH and H-Ala-Arg-Pro-Ala-OH are obtained with yields of 86% and 85%, respectively[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-L-Ala-OH Related Antibodies
Molecular Weight

189.21

Formula

C8H15NO4
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (528.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2851 mL 26.4257 mL 52.8513 mL
5 mM 1.0570 mL 5.2851 mL 10.5703 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation

Purity: 99.07%

SDS (393 KB)

COA (249 KB) HNMR (154 KB) RP-HPLC (176 KB) LCMS (331 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2851 mL 26.4257 mL 52.8513 mL 132.1283 mL
5 mM 1.0570 mL 5.2851 mL 10.5703 mL 26.4257 mL
10 mM 0.5285 mL 2.6426 mL 5.2851 mL 13.2128 mL
15 mM 0.3523 mL 1.7617 mL 3.5234 mL 8.8086 mL
20 mM 0.2643 mL 1.3213 mL 2.6426 mL 6.6064 mL
25 mM 0.2114 mL 1.0570 mL 2.1141 mL 5.2851 mL
30 mM 0.1762 mL 0.8809 mL 1.7617 mL 4.4043 mL
40 mM 0.1321 mL 0.6606 mL 1.3213 mL 3.3032 mL
50 mM 0.1057 mL 0.5285 mL 1.0570 mL 2.6426 mL
60 mM 0.0881 mL 0.4404 mL 0.8809 mL 2.2021 mL
80 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6516 mL
100 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3213 mL
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Boc-L-Ala-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-L-Ala-OH15761-38-3Boc-Ala-OHAmino Acid Derivativesprotected L-alanine derivativeracemic pivaloyl-protected 3-chloromandelic acidmono-N-protected amino acid ligandepidermoid squamous carcinomabetulin amino acid estersP6A metabolitesprotected peptide intermediatesPd(II)-catalyzed enantioselective C-H olefination/kinetic resolutionpeptide synthesisliver-targeted glycogen phosphorylase inhibitor conjugatesInhibitorinhibitorinhibit

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