Lyso-PAF C-16
Based on 1 publication(s) in Google Scholar
Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.87%
- CAS 番号: 52691-62-0
- 分子式: C24H52NO6P
- 分子量:481.65
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Lyso-PAF C-16
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
5.5 μg/mL
Compound: 1
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Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
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[PMID: 11325244] |
| HCT-15 | ED50 |
5.4 μg/mL
Compound: 1
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Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay
Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay
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[PMID: 11325244] |
| SK-MEL3 | ED50 |
5.4 μg/mL
Compound: 1
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Cytotoxicity against human SK-MEL-3 cells after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-3 cells after 48 hrs by SRB assay
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[PMID: 11325244] |
| SK-OV-3 | ED50 |
4.9 μg/mL
Compound: 1
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Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
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[PMID: 11325244] |
| XF498 | ED50 |
4.9 μg/mL
Compound: 1
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Cytotoxicity against human XF498 cells after 48 hrs by SRB assay
Cytotoxicity against human XF498 cells after 48 hrs by SRB assay
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[PMID: 11325244] |
体外実験
Lyso-PAF C-16 (5-50 μM; 20 min preincubation, 20 min ATP incubation) increases plasma membrane Ca2+-ATPase activity by approximately 50% in rat brain synaptosomal membranes, with peak activity at 20-30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 52691-62-0
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性状 Solid
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分子量 481.65
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分子式 C24H52NO6P
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
H2O : 20 mg/mL (41.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Grosman N, et al. Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. Int Immunopharmacol. 2001;1(7):1321-1329. [Content Brief]
[2]. Uemura Y, et al. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem. 1991 May 5;266(13):8268-72. [Content Brief]
[3]. Venable ME, et al. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. J Biol Chem. 1993 Apr 15;268(11):7965-75. [Content Brief]
[4]. Yamaura S, et al. Novel enzymatic method for assaying Lp-PLA2 in serum. Clin Chim Acta. 2018 Jun;481:184-188. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0762 mL | 10.3810 mL | 20.7620 mL | 51.9049 mL |
| 5 mM | 0.4152 mL | 2.0762 mL | 4.1524 mL | 10.3810 mL | |
| 10 mM | 0.2076 mL | 1.0381 mL | 2.0762 mL | 5.1905 mL | |
| 15 mM | 0.1384 mL | 0.6921 mL | 1.3841 mL | 3.4603 mL | |
| 20 mM | 0.1038 mL | 0.5190 mL | 1.0381 mL | 2.5952 mL | |
| 25 mM | 0.0830 mL | 0.4152 mL | 0.8305 mL | 2.0762 mL | |
| 30 mM | 0.0692 mL | 0.3460 mL | 0.6921 mL | 1.7302 mL | |
| 40 mM | 0.0519 mL | 0.2595 mL | 0.5190 mL | 1.2976 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lyso-PAF C-16 関連分類
HY-141570 関連分類
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