Lyso-PAF C-16-d4
Lyso-PAF C-16-d4 (Lyso-platelet-activating factor C-16-d4) is the deuterated-labeled Lyso-PAF C-16 (HY-141570). Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase.
For research use only. We do not sell to patients.
- CAS No.: 201216-37-7
- Formula: C24H48D4NO6P
- Molecular Weight:485.67
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 201216-37-7
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Unlabeled Cas 52691-62-0
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Appearance Liquid
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Molecular Weight 485.67
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Formula C24H48D4NO6P
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Color Colorless to light yellow
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SMILES
CCCCCCCCC([2H])([2H])C([2H])([2H])CCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
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Synonyms
Lyso-platelet-activating factor C-16-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (263 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Grosman N, et al. Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. Int Immunopharmacol. 2001;1(7):1321-1329. [Content Brief]
[2]. Uemura Y, et al. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem. 1991 May 5;266(13):8268-72. [Content Brief]
[3]. Venable ME, et al. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. J Biol Chem. 1993 Apr 15;268(11):7965-75. [Content Brief]
[4]. Yamaura S, et al. Novel enzymatic method for assaying Lp-PLA2 in serum. Clin Chim Acta. 2018 Jun;481:184-188. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lyso-PAF C-16-d4 Related Classifications
HY-141570S Related Classifications
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- Lyso-PAF C-16-d4
- 201216-37-7
- Lyso-platelet-activating factor C-16-d4
- Isotope-Labeled Compounds
- Phospholipase
- rat brain synaptosomal membranes
- Ca2+-ATPase
- rat mixed peritoneal leukocyte membranes
- rat peritoneal leukocyte membrane
- allergic reactions
- inflammatory reactions
- ether phospholipid derivative
- plasma membrane Ca2+-ATPase
- Inhibitor
- inhibitor
- inhibit