52691-62-0
52691-62-0
Chemical Structure
Lyso-PAF C-16
- CAS No.: 52691-62-0
- Formula:C24H52NO6P
- Molecular Weight:481.65
IUPAC Name: (R)-3-(hexadecyloxy)-2-hydroxypropyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: VLBPIWYTPAXCFJ-XMMPIXPASA-N
SMILES: CCCCCCCCCCCCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
Biological Activity: Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lyso-PAF C-16 | 99.5% | Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase. | ||||||||||||||||||||
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Lyso-PAF C-16-d4 | Lyso-PAF C-16-d4 (Lyso-platelet-activating factor C-16-d4) is the deuterated-labeled Lyso-PAF C-16 (HY-141570). Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase. | |||||||||||||||||||||
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References
- [1]. Grosman N, et al. Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. Int Immunopharmacol. 2001;1(7):1321-1329. [Content Brief]
- [2]. Uemura Y, et al. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem. 1991 May 5;266(13):8268-72. [Content Brief]
- [3]. Venable ME, et al. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. J Biol Chem. 1993 Apr 15;268(11):7965-75. [Content Brief]
- [4]. Yamaura S, et al. Novel enzymatic method for assaying Lp-PLA2 in serum. Clin Chim Acta. 2018 Jun;481:184-188. [Content Brief]
Keywords
