Lyso-PAF C-18
Based on 1 Customer Validation
Lyso-PAF C-18 is a single-chain ether phospholipid with membrane regulatory activity, and Lyso-PAF is the deacetylated inactive precursor of PAF. Lyso-PAF C-18 regulates the activity of plasma membrane Ca2+-ATPase, and its mechanism of action may involve altering the lipid microenvironment of this enzyme. Lyso-PAF C-18 activates the calcium ATPase in rat synaptosomal membranes and inhibits the calcium ATPase in rat leukocyte membranes. Lyso-PAF C-18 can be used in cell membrane-related research.
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- Purity: 99.74%
- CAS No.: 74430-89-0
- 화학식: C26H56NO6P
- 분자량:509.70
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
18 μM
Compound: 7b
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Cytotoxicity against human HT-29 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as cell viability after 48 hrs by MTT assay
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[PMID: 19402667] |
Lyso-PAF C-18 forms highly stable Langmuir monolayers at 20 °C under 20 mN/m, whereas its monolayer stability declines at 35 mN/m[1].
Lyso-PAF C-18 (5-50 μM; 20 min preincubation, followed by 20 min incubation with ATP) increases the plasma membrane Ca2+-ATPase activity of rat brain synaptosomal membranes by approximately 50%, while it inhibits the plasma membrane Ca2+-ATPase activity of rat peritoneal leukocyte membranes by 48%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 74430-89-0
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Appearance Solid
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분자량 509.70
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화학식 C26H56NO6P
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lyso-PAF C-18 Related Classifications
HY-141581 Related Classifications
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