74430-89-0
Chemical Structure
Lyso-PAF C-18
- CAS No.: 74430-89-0
- Formula:C26H56NO6P
- Molecular Weight:509.70
IUPAC Name: (R)-2-hydroxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: XKBJVQHMEXMFDZ-AREMUKBSSA-N
SMILES: CCCCCCCCCCCCCCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
Biological Activity: Lyso-PAF C-18 is a single-chain ether phospholipid with membrane regulatory activity, and Lyso-PAF is the deacetylated inactive precursor of PAF. Lyso-PAF C-18 regulates the activity of plasma membrane Ca2+-ATPase, and its mechanism of action may involve altering the lipid microenvironment of this enzyme. Lyso-PAF C-18 activates the calcium ATPase in rat synaptosomal membranes and inhibits the calcium ATPase in rat leukocyte membranes. Lyso-PAF C-18 can be used in cell membrane-related research[1][2].
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Lyso-PAF C-18 | 99.74% | Lyso-PAF C-18 is a single-chain ether phospholipid with membrane regulatory activity, and Lyso-PAF is the deacetylated inactive precursor of PAF. Lyso-PAF C-18 regulates the activity of plasma membrane Ca2+-ATPase, and its mechanism of action may involve altering the lipid microenvironment of this enzyme. Lyso-PAF C-18 activates the calcium ATPase in rat synaptosomal membranes and inhibits the calcium ATPase in rat leukocyte membranes. Lyso-PAF C-18 can be used in cell membrane-related research. | ||||||||||||||||||||
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Lyso-PAF C-18-d4 | Lyso-PAF C-18-d4 is the deuterated-labeled Lyso-PAF C-18 (HY-141581). Lyso-PAF C-18 is a single-chain ether phospholipid with membrane regulatory activity, and Lyso-PAF is the deacetylated inactive precursor of PAF. Lyso-PAF C-18 regulates the activity of plasma membrane Ca2+-ATPase, and its mechanism of action may involve altering the lipid microenvironment of this enzyme. Lyso-PAF C-18 activates the calcium ATPase in rat synaptosomal membranes and inhibits the calcium ATPase in rat leukocyte membranes. Lyso-PAF C-18 can be used in cell membrane-related research. | |||||||||||||||||||||
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References
- [1]. Flasiński M, et al. Comparative characteristics of membrane-active single-chained ether phospholipids: PAF and lyso-PAF in Langmuir monolayers. The journal of physical chemistry. B. 2012 Mar 15;116(10):3155-63. [Content Brief]
- [2]. Grosman N. Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca²⁺-ATPase activity of rat brain synaptosomes and leukocyte membranes. International Immunopharmacology, 2001, 1(7): 1321-1329.
