(R)-Edelfosine
Based on 1 Customer Validation
(R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 77286-66-9
- Formula: C27H58NO6P
- Molecular Weight:523.73
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
5.05 μM
Compound: 1
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Inhibitor activity against A549 (Human lung carcinoma)cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against A549 (Human lung carcinoma)cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| AMML | IC50 |
3.3 μM
Compound: 1
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Compound was tested for the inhibition of AMML (acute myelomonocytic leukemia)
Compound was tested for the inhibition of AMML (acute myelomonocytic leukemia)
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[PMID: 3761322] |
| CML/BC | IC50 |
1.5 μM
Compound: 1
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Compound was tested for the inhibition of CML/BC(chronic myeloid leukemia, blast crisis)
Compound was tested for the inhibition of CML/BC(chronic myeloid leukemia, blast crisis)
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[PMID: 3761322] |
| Glioblastoma cell line | IC50 |
20 μM
Compound: 1
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Compound was tested for the inhibition of glioblastoma
Compound was tested for the inhibition of glioblastoma
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[PMID: 3761322] |
| HL-60 | IC50 |
2.5 μM
Compound: 1
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Compound was tested for the inhibition of human HL60 Leukemia
Compound was tested for the inhibition of human HL60 Leukemia
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[PMID: 3761322] |
| HT-29 | GI50 |
2.2 μM
Compound: 1
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Inhibitor activity against HT-29 (Human colon carcinoma)cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against HT-29 (Human colon carcinoma)cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| L1210 | GI50 |
10.99 μM
Compound: 1
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Inhibitor activity against L1210/vmdr (transfected with a plasmid containing mdr1) cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against L1210/vmdr (transfected with a plasmid containing mdr1) cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| L1210 | GI50 |
3.32 μM
Compound: 1
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Inhibitor activity against L1210 (murine leukemia )cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against L1210 (murine leukemia )cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| Lewis lung carcinoma cell line | GI50 |
30.24 μM
Compound: 1
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Inhibitor activity against Lewis lung (murine lung carcinoma)cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against Lewis lung (murine lung carcinoma)cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| MCF7 | GI50 |
30.35 μM
Compound: 1
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Inhibitor activity against MCF-7/Adr (Human colon carcinoma)cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against MCF-7/Adr (Human colon carcinoma)cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| MCF7 | GI50 |
9.66 μM
Compound: 1
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Inhibitor activity against MCF-7(Human breast carcinoma)cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against MCF-7(Human breast carcinoma)cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| NSCLC | IC50 |
21 μM
Compound: 1
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Compound was tested for the inhibition of non- small cell lung cancer
Compound was tested for the inhibition of non- small cell lung cancer
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[PMID: 3761322] |
| P388 | GI50 |
4.33 μM
Compound: 1
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Inhibitor activity against P388 (murine leukemia )cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against P388 (murine leukemia )cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| P388 | GI50 |
6.39 μM
Compound: 1
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Inhibitor activity against P388/Adr (murine leukemia )cell line with varying concentration of the drug for 72 hrs
Inhibitor activity against P388/Adr (murine leukemia )cell line with varying concentration of the drug for 72 hrs
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[PMID: 8765506] |
| RBL-2H3 | IC50 |
7.1 μM
Compound: 1
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Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release
Inhibition of rat RBL2H3 cell granulation assessed as reduction of beta hexasaminidase release
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[PMID: 20153565] |
| Small cell lung cancer cell line | IC50 |
24 μM
Compound: 1
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Compound was tested for the inhibition of small cell lung cancer
Compound was tested for the inhibition of small cell lung cancer
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[PMID: 3761322] |
Chemical Information
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CAS No. 77286-66-9
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Appearance Solid
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Molecular Weight 523.73
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Formula C27H58NO6P
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(OCC[N+](C)(C)C)([O-])=O
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Synonyms
(R)-ET-18-OCH3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 10 mg/mL (19.09 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (262 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.9094 mL | 9.5469 mL | 19.0938 mL | 47.7345 mL |
| 5 mM | 0.3819 mL | 1.9094 mL | 3.8188 mL | 9.5469 mL | |
| 10 mM | 0.1909 mL | 0.9547 mL | 1.9094 mL | 4.7735 mL | |
| 15 mM | 0.1273 mL | 0.6365 mL | 1.2729 mL | 3.1823 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(R)-Edelfosine Related Classifications
HY-108610 Related Classifications
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